复方芪麻胶囊对原发性高血压患者脂联素及动脉弹性的影响

发布时间：2018-02-11 22:18

  本文关键词： 复方芪麻胶囊 原发性高血压 脂联素 动脉僵硬度　出处：《辽宁中医杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的:观察复方芪麻胶囊对高血压患者血清脂联素(Adiponectin,APN)水平及动脉僵硬度的影响,探讨中医药对高血压的防治作用。方法:将84例原发性高血压患者按照完全随机化分为治疗组和对照组各42例,两组分别给予基础降压药替米沙坦片(80 mg,1次/d),治疗组在此基础上加用复方芪麻胶囊(2粒/次,3次/d),同时选取30例健康体检者作为健康对照组。给药8周后,比较治疗前后两组患者的收缩压、舒张压、脂联素水平及臂-踝脉搏波传导速度(Ba-PWV)。结果:EH患者的APN水平较健康人群明显降低,Ba-PWV显著增加,具有统计学意义(P0.01);治疗8周后,治疗组及对照组的SBP、DBP、APN、Ba-PWV较治疗前有明显改善,且在降低SBP及APN水平方面治疗组比对照组更有优势(P0.05)。结论:复方芪麻胶囊可显著增加EH患者脂联素水平,推测这可能是其改善高血压动脉僵硬度的机制之一。
[Abstract]:Objective: to observe the effect of compound Qima capsule on serum adiponectin (Adiponectin) and arterial stiffness in patients with hypertension. Methods: 84 patients with essential hypertension were randomly divided into treatment group (n = 42) and control group (n = 42). The two groups were given the basic antihypertensive drug telmisartan (80 mg / d), and the treatment group was treated with 2 capsules of compound Qima capsule / 3 times / d, and 30 healthy persons were selected as the healthy control group. After 8 weeks of administration, the treatment group was treated with two capsules of compound Qima capsule, and 30 healthy persons were selected as the control group. Systolic blood pressure (SBP), diastolic blood pressure (DBP), adiponectin level and brachial-ankle pulse wave velocity (BWV) were compared between the two groups before and after treatment. Results the APN level in patients with BALB / EH was significantly lower than that in healthy subjects (P 0.01). Compared with the control group, the treatment group and the control group had obvious improvement in SBP DBPU Ba-PWV, and the treatment group had more advantages than the control group in reducing the levels of SBP and APN. Conclusion: compound Qi-ma capsule can significantly increase the adiponectin level in EH patients. It is speculated that this may be one of its mechanisms to improve arterial stiffness of hypertension.
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