急性心肌梗死热毒证候病因探讨回顾性分析

发布时间：2018-02-12 13:53

本文关键词： 急性心肌梗死热毒证候危险因素血脂代谢紊乱　出处：《中国实验方剂学杂志》2017年11期 　论文类型：期刊论文

【摘要】：目的:探讨急性心肌梗死热毒证患者的危险因素,对其证候病因进行分析。方法:回顾性筛选收集广州中医药大学第一附属医院确诊为急性心肌梗死患者的临床资料,进行中医证候分布调查,并将其分为热毒证组及非热毒证组,分析两组的一般资料以及住院病情预后,并采用Logistic回归分析热毒证病因的危险因素。结果:研究纳入322例患者中热毒证组占42.20%(136例),非热毒证组占57.8%(186例)。热毒证组平均血管病变数、左室舒张末、左室射血分数明显差于非热毒组(P0.05),住院期间心血管死亡例数两组未见明显差异。单因素分析热毒证分布为吸烟、辛辣厚味饮食、糖尿病、高脂血症多重心血管危险因素聚集人群(P0.05),Logistic回归分析发现吸烟、低密度脂蛋白、甘油三酯3个因子是预测热毒证候病因的独立要素,比值比(OR)分别为1.755,1.637,1.483。结论:急性心肌梗死热毒证形成病因与吸烟、血脂代谢紊乱相关,住院期间预后与非热毒证未见差异,但心室重构程度重于非热毒证组。
[Abstract]:Objective: to investigate the risk factors of acute myocardial infarction with heat toxin syndrome and analyze the etiology of its syndrome. Methods: the clinical data of the patients diagnosed as acute myocardial infarction in the first affiliated Hospital of Guangzhou University of traditional Chinese Medicine were collected retrospectively. To investigate the distribution of TCM syndromes, and divide them into heat toxin syndrome group and non heat toxin syndrome group, and analyze the general data of the two groups and the prognosis of hospitalization. Logistic regression analysis was used to analyze the risk factors of heat toxin syndrome. Results: among 322 patients, heat toxin syndrome group accounted for 42. 20 cases and non-heat toxin syndrome group accounted for 57. 8%. The mean number of vascular lesions and left ventricular diastolic end in heat toxin syndrome group were 57.8%. The left ventricular ejection fraction (LVEF) was significantly lower than that in the non-heat toxic group (P 0.05). There was no significant difference in the number of cardiovascular deaths between the two groups during hospitalization. Logistic regression analysis showed that smoking, low density lipoprotein and triglyceride were independent factors in predicting the etiology of heat toxin syndrome. The ratio of ORs to OR was 1.7551.637and 1.483.Conclusion: the etiology of heat toxin syndrome in acute myocardial infarction is related to smoking, dyslipidemia, and the prognosis during hospitalization is not different from that of non-heat toxic syndrome, but the degree of ventricular remodeling is more serious than that of non-heat toxic syndrome.
【作者单位】：广州中医药大学第一附属医院;广州中医药大学;
【基金】：国家中医临床研究基地业务建设科研专项(JDZX2015241)
【分类号】：R259

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