金黄散外敷恶性肿瘤包块的临床疗效观察

发布时间：2018-02-14 06:09

本文关键词： 金黄散外敷恶性肿瘤临床疗效　出处：《成都中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：观察中药金黄散外敷治疗恶性肿瘤浅表包块的临床疗效,为临床恶性肿瘤治疗提供一种新方法。方法：本课题主要选取84例腹膜转移癌、肝癌、淋巴结转移癌疾病患者为例,其中腹膜转移癌30例,肝癌30例,淋巴结转移癌24例,每天采用金黄散外敷肿瘤浅表包块或者癌性疼痛部位至肿瘤治疗无效或者本课题研究结束为止。观察治疗后恶性肿瘤包块的有效率、控制率以及1个月、3个月、6个月疗效维持有效率；肿瘤癌性疼痛缓解有效率、1个月、3个月、6个月疗效维持有效率；肿瘤患者KPS评分疗效变化情况等。结果：1.纳入本课题符合诊断标准的恶性肿瘤患者84例,其中1例因局部皮肤严重瘙痒、皮疹,给予抗过敏、止痒等对症处理后退出本试验,最终符合标准的患者83例。2.金黄散外敷治疗肿瘤有效率为10%～21.73%,控制率40%～56.52%,包块疗效维持1个月为80%-82%,三个月有效率为70%-78%,6个月有效率为40%～72%。其中肿瘤控制有效率以淋巴结转移癌控制率最高,经组间分析,淋巴结转移癌与腹膜转移癌经统计学分析,差异具有统计学意义(P=0.0350.05),淋巴结转移癌与肝癌经统计学分析,差异具有统计学意义(P=0.015＜0.05)。3.金黄散外敷治疗后肿瘤疼痛有效率90%-96%,1个月疗效维持83%-85%,三个月有效率为75%～80%,6个月有效率为70%～75%。其中疼痛缓解以肝癌有效率最高,经组间分析,肝癌与腹膜转移癌经统计学分析,差异具有统计学意义(P=0.023＜0.05),淋巴结转移癌与肝癌经统计学分析,差异具有统计学意义(P=0.025＜0.05)。4.金黄散外敷治疗后肿瘤患者KPS评分改善率为43%-52%。结论：金黄散外敷恶性肿瘤不仅具有控制恶性肿瘤浅表包块的作用,还具有缓解癌性疼痛和改善患者生存质量的作用,值得临床上进一步推广。
[Abstract]:Objective: to observe the clinical effect of Jinhuangsan on superficial mass of malignant tumor, and to provide a new method for the treatment of malignant tumor. Methods: 84 cases of peritoneal metastatic carcinoma and liver cancer were selected in this study. There were 30 cases of peritoneal metastatic carcinoma, 30 cases of liver cancer and 24 cases of lymph node metastasis. Apply Jinhuangsan to the superficial tumor mass or cancerous pain area every day until the tumor treatment is ineffective or until the end of this study. Observe the effective rate of malignant tumor mass after treatment. The control rate and the effective rate of 1 month, 3 months and 6 months were maintained, and the effective rate of cancer pain relief was maintained at 1 month, 3 months and 6 months. Results 1. 84 patients with malignant tumors who met the diagnostic criteria were included in the study. One patient withdrew from the trial because of severe local skin itching, rash, antiallergic, antipruritic, antipruritic, and other symptomatic treatments. The effective rate of external application of Jinhuangsan in the treatment of tumor was 100.21.73. the control rate was 4056.52.The effective rate was 80-82 for one month, the effective rate for three months was 70-78, and the effective rate for 6 months was 400.72.The effective rate of tumor control was transformed into lymph node. The cancer control rate is the highest. The difference between lymph node metastatic carcinoma and peritoneal metastatic carcinoma was statistically significant, and the difference between lymph node metastatic carcinoma and hepatocellular carcinoma was statistically significant. The difference was statistically significant (P < 0.015 < 0.05) .3.The effective rate of tumor pain after external application of Jinhuang Powder was 90-96.The curative effect maintained 83-85 for one month, 7580 for three months, 70th for 6 months. The highest effective rate was liver cancer, which was analyzed by inter-group analysis. The difference between hepatocellular carcinoma and peritoneal metastatic carcinoma was statistically significant (P < 0.023 < 0.05), and that between lymph node metastatic carcinoma and hepatocellular carcinoma was statistically significant. The difference was statistically significant (P < 0.025 < 0.05) .4.The improvement rate of KPS score in patients with tumor after external application of Jinhuang Powder was 43- 52.Conclusion: external application of Jinhuang Powder can not only control the superficial mass of malignant tumor. It also has the function of relieving cancer pain and improving the quality of life of patients, which is worth further popularizing in clinic.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R273

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