通心络对颈动脉粥样硬化远期疗效的随访研究

发布时间：2018-02-14 09:35

  本文关键词： 通心络 动脉粥样硬化 颈动脉斑块 随访研究　出处：《山东中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:通过检测动脉粥样硬化患者颈动脉超声及血脂、血糖、超敏C反应蛋白、纤维蛋白原等临床生化指标,探究中成药通心络对动脉粥样硬化治疗的远期作用。方法:将颈动脉粥样硬化患者108例,随机分为通心络组72例、对照组36例,治疗24个月后将通心络组分为持续通心络组36例、停服通心络组36例,并随访24个月。检测患者基线、服药24个月及48个月后的颈动脉超声指标及血脂、血糖、hs-CRP、Fib等生化指标随时间的变化情况以评估治疗效果。结果:至2015年12月,原108人中106人完成随访,其中1例因出现肝功能异常退出,1例死亡(死于肺部感染),结果表明:1、颈动脉斑块指标:24个月后患者颈动脉B超示通心络组颈动脉斑块内中膜厚度(IMT)及长轴面积(LS)优于对照组(P0.05);斑块短轴面积(SS)两组间差别无统计学意义(P0.05)。随访48个月后,持续通心络组与停服通心络组间颈动脉内中膜厚度(IMT)差异无统计学意义(p0.05),但均优于对照组(P0.05);持续通心络组斑块短轴面积(SS)优于对照组(P0.05);持续服用通心络组斑块长轴面积(LS)优于停服通心络组及对照组(P0.05),余组间差别无统计学意义。2、生化指标:48个月后持续通心络组低密度脂蛋白胆固醇、超敏C反应蛋白水平小于对照组(P0.05)。持续通心络组纤维蛋白原低于对照组(P0.05)及停服通心络组(P0.01),余组间差别无统计学意义。总胆固醇、高密度脂蛋白胆固醇、甘油三酯、谷丙转氨酶、肌酐等指标各组间无明显统计学差异。结论:1.通心络有稳定动脉粥样硬化的作用,可能通过改善低密度脂蛋白胆固醇、超敏C反应蛋白、纤维蛋白原等途径延缓动脉粥样硬化的进程。2.服用通心络一段时间后停服仍能起到稳定斑块的作用,其内中膜厚度仍维持在较低水平。但持续服用通心络有优于服用一段时间后停服通心络的趋势,故应持续服用通心络,以达到最佳的治疗效果。
[Abstract]:Objective: through the carotid artery atherosclerosis in patients with ultrasound and blood lipid, blood glucose, high sensitive C reactive protein, fibrinogen and other clinical biochemical indexes, explore Chinese medicine Tongxinluo on the long-term effects of treatment for atherosclerosis. Methods: 108 patients with carotid atherosclerosis were randomly divided into Tongxinluo group 72 cases, 36 cases in the control group. After 24 months of treatment will be divided into Tongxinluo Group continued Tongxinluo group in 36 cases, stop taking Tongxinluo group in 36 cases, and were followed up for 24 months. Patients were examined at baseline, after 24 months and 48 months after the carotid artery ultrasound index and blood lipid, blood glucose, hs-CRP, Fib and other changes biochemical index with time to assess the effect of treatment. Results: to December 2015, the original 108 people 106 people completed the follow-up, including 1 cases with abnormal liver function exit, 1 cases of death (died of pulmonary infection), the results showed that: 1, carotid artery plaque index: 24 months after carotid artery ultrasound scan 閫氬績缁滅粍棰堝姩鑴夋枒鍧楀唴涓�鑶滃帤搴�(IMT)鍙婇暱杞撮潰绉，

本文编号：1510399