温补心肾阳气法治疗缓慢型心律失常临床疗效的Meta分析

发布时间：2018-02-14 15:06

本文关键词： 温补心肾阳气缓慢型心律失常 Meta分析 RCT试验　出处：《辽宁中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:Meta分析温补心肾阳气中药干预缓慢型心律失常的临床疗效,为温补心肾阳气中药治疗缓慢型心律失常应用于临床提供循证医学证据。方法:制定科学全面的检索策略,严格制定文献的纳入标准和排除标准,用计算机检索和手动检索相配合的方法检索2011-2015年公开发表的中文文献,关于温补心肾阳气法配合西药常规治疗缓慢型心律失常的RCT试验。并将最终纳入的文献进行资料的录入和Jadad评分,评出每一篇纳入文献的质量,用Rev Man5.3统计软件进行二分类资料或连续性资料的meta分析。结果:本次分析一共纳入15篇文献,包括2篇高质量文献,13篇低质量文献。共纳入病例1354例,其中治疗组(温补心肾阳气中药配合基础西药)698例患者,对照组(基础西药或加安慰剂)656例患者。Meta分析的结果显示:(1)在提高患者临床有效率方面:治疗组疗效优于对照组,差异有统计学意义(OR=3.78,95%CI=2.75~5.18,Z=8.23,P0.00001);(2)在改善中医证候疗效方面:治疗组疗效优于对照组,差异有统计学意义(OR=6.39,95%CI=3.20~12.76,Z=5.26,P0.00001);(3)在提高患者24小时平均心率方面:治疗组疗效优于对照组,差异有统计学意义(MD=5.22,95%CI=4.41~6.03,假设检验Z=12.69,P0.00001);(4)在提高患者24小时最慢心率方面:治疗组疗效优于对照组,差异有统计学意义(MD=5.65,95%CI=4.92~6.38,假设检验Z=15.16,P0.00001)。结论:温补心肾阳气中药配合常规西药治疗能够明显提高缓慢型心律失常患者临床有效率,改善患者症状,提高患者24小时平均心率及最低心率,临床疗效显著,且安全性较好。
[Abstract]:Objective to analyze the clinical efficacy of Chinese medicine for warming heart and kidney yang qi in treating bradyarrhythmia, and to provide evidence for clinical application of traditional Chinese medicine for warming heart and kidney yang qi in the treatment of slow arrhythmia. Methods: a scientific and comprehensive search strategy was formulated. To strictly formulate the inclusion criteria and exclusion criteria for literature, and to search the Chinese literature published in 2011-2015 by means of computer retrieval and manual retrieval. The RCT test of tonifying the heart and kidney yang qi combined with the routine western medicine for the treatment of bradyarrhythmia was conducted. The data input and Jadad score of the final literature were recorded, and the quality of each article was evaluated. Rev Man5.3 statistical software was used to analyze the two classification data or continuous data by meta. Results: 15 articles were included in this analysis, including 2 high quality literatures and 13 low quality articles. 1354 cases were included in this analysis. Among them, 698 patients in treatment group (warming heart and kidney yang qi Chinese medicine combined with basic western medicine) and 656 patients in control group (basic western medicine or placebo + placebo 656 patients. Meta analysis showed that: the curative effect of treatment group was better than that of control group) in improving the clinical effective rate of patients. The difference is statistically significant: the curative effect of the treatment group is better than that of the control group, and the difference is statistically significant. The treatment group is better than the control group, and the difference is statistically significant. The treatment group is better than the control group in improving the mean heart rate of 24 hours. The treatment group is superior to the control group in improving the mean heart rate of 24 hours. The difference was statistically significant (P < 0.05). The effect of the treatment group was better than that of the control group in increasing the slowest heart rate in 24 hours. The difference was statistically significant (P < 0.01). Conclusion: the clinical effective rate and symptoms of patients with chronic arrhythmia can be obviously improved by warming the heart and nourishing the kidney yang qi with the Chinese medicine of warming the heart and kidney yang qi, and the routine western medicine, and the hypothesis test is that the Chinese herbal medicine for warming the heart and kidney yang qi combined with the routine western medicine can obviously improve the clinical effective rate and improve the symptoms of the patients with bradyarrhythmia. The improvement of 24-hour mean heart rate and minimum heart rate was effective and safe.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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