舒郁清脑颗粒治疗紧张型头痛肝郁气滞证的临床疗效观察

发布时间：2018-02-16 09:06

本文关键词： 舒郁清脑颗粒紧张型头痛肝郁气滞证临床研究　出处：《湖南中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：观察舒郁清脑颗粒治疗肝郁气滞型紧张型头痛的临床疗效并进行安全性评价。方法：本研究共纳入68例患者,采用随机平行对照方法,将符合纳入标准的病例,按Doll's临床病例随机表,分为治疗组和对照组,每组各34例。治疗组：基础治疗上加服舒郁清脑颗粒,用温开水冲服,每日1剂(11.64g),分2次服；对照组：基础治疗上加服盐酸替扎尼定片,2mg/次,每日3次,两组均治疗28天。治疗期间,如合并高血压、糖尿病等基础疾病,可予相关治疗,禁用镇静、止痛及抗抑郁药或疏肝解郁中药。治疗前后分别对每个组患者进行头痛指数综合评分、经颅多普勒(TCD)的VS(收缩期峰血流速度)检测、中医证候积分表评分,进行血尿常规、肝肾功能、血糖、心电图检测,通过SPSS17.0进行统计分析,比较两组疗效并进行安全性评价。结果：1.在改善紧张型头痛发作症状方面,总有效率治疗组91.1%,对照组85.2%,治疗组疗效明显优于对照组(P0.05)。两组治疗后与治疗前相比,头痛指数下降明显,差异有统计学意义(P0.05),治疗后与对照组相比,治疗组头痛指数改善明显,差异有统计学意义(P0.05)。2.在改善中医证候方面,总有效率治疗组94.1%,对照组82.3%,治疗组的疗效明显优于对照组(P0.05)。两组治疗后与治疗前相比,中医证候积分改善明显,差异有统计学意义(P0.05)；治疗后与对照组相比,治疗组中医证候积分显著降低,差异有统计学意义(P0.05)。3.在改善头部血流方面,与治疗前相比,两组治疗后经颅多普勒(TCD)的VS(收缩期峰血流速度)检测降低,差异具有统计学意义(P0.05);治疗后与对照组相比,治疗组经颅多普勒(TCD)的VS(收缩期峰血流速度)检测改善明显,差异有统计学意义(P0.05)。结论：舒郁清脑颗粒治疗肝郁气滞型紧张型头痛,临床使用安全,疗效确切。能有效改善患者头部血管血流速度,降低血管痉挛状态,从而缓解患者临床症状,其临床疗效优于替扎尼定片。
[Abstract]:Objective: to observe the clinical efficacy and safety evaluation of Shuyuqing Naonao granule in the treatment of tension type headache with stagnation of liver and qi. Methods: 68 patients were included in this study. According to the clinical cases of Doll's, they were randomly divided into treatment group (n = 34) and control group (n = 34). Control group: basic treatment plus 2 mg / time of tizanidine hydrochloride, 3 times a day, both groups were treated for 28 days. During the treatment period, such as hypertension, diabetes and other basic diseases, may be related treatment, no sedation, Before and after treatment, the patients in each group were given comprehensive score of headache index, VS- (peak systolic blood flow velocity) of transcranial Doppler (TCD), score of TCM syndromes integral table, routine blood and urine routine, respectively, before and after treatment with antidepressant and antidepressant drugs or traditional Chinese medicine for soothing the liver and relieving depression. Liver and kidney function, blood glucose and electrocardiogram were measured, and SPSS17.0 was used to analyze the efficacy and safety of the two groups. Results: 1. In improving the symptoms of tension headache, The total effective rate was 91.1% in the treatment group and 85.2% in the control group. The curative effect of the treatment group was significantly better than that of the control group (P 0.05). After treatment, the headache index of the two groups decreased significantly and the difference was statistically significant (P 0.05). After treatment, the headache index of the treatment group was significantly improved compared with that of the control group. In improving TCM syndrome, the total effective rate of the treatment group was 94.1 and that of the control group was 82.3. The curative effect of the treatment group was significantly better than that of the control group P0.050.Compared with that before treatment, the score of TCM syndromes in the two groups was obviously improved. Compared with the control group, the scores of TCM syndromes in the treatment group were significantly lower than those in the control group, and the difference was statistically significant (P 0.05). 3. In improving the blood flow of the head, compared with before treatment, After treatment, the VS (peak systolic velocity) of TCDs in the treatment group was significantly lower than that in the control group (P 0.05), and the VS (peak systolic velocity) measurement of TCD in the treatment group was significantly improved compared with that in the control group. Conclusion: Shuyuqing Nao granule is safe and effective in the treatment of tension type headache of liver stagnation and qi stagnation. It can effectively improve the blood flow velocity and reduce the vasospasm of the head of the patients. In order to alleviate the clinical symptoms of patients, its clinical efficacy is better than that of tezanidine tablets.
【学位授予单位】：湖南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7

【相似文献】