脑梗死恢复期血瘀质用药规律研究

发布时间：2018-02-22 02:53

本文关键词： 血瘀质脑梗死关联规则用药规律　出处：《山东中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:采用关联规则分析血瘀质脑梗死恢复期患者用药规律,为临床预防治疗提供用药参考。方法:依照流行病学调查方法,选取山东省中医院、烟台市中医医院、蓬莱市中医医院等不同地域、不同级别的3家中医院中处于恢复期的脑梗死血瘀质患者,收集其处方用药,运用SPSS Clementine 12.0数据挖掘软件对该数据所含药物进行关联规则挖掘研究,以获得相互关联的药对,并对其进行相关性分析。结果:本研究共获得处方400首,中药242味,使用频次在25次(包括25次)以上的药物共49种。使用频次在前五位的药类依次是活血化瘀药、补虚药、清热药、化痰止咳平喘药、平肝息风药。共获得规则250条,出现规则最多的药物是红花,其次是桃仁、当归、川芎、赤芍等。其中支持度较高的规则有:甘草+红花→桃仁(支持度23.00%,提升为1.39%),甘草+川芎→红花(支持度18.75%,提升为1.227%),当归+红花→桃仁(支持度20.5%,提升为1.448%),当归+红花→川芎(支持度20.5%,提升为1.7%),白术+红花→桃仁(支持度18.5%,提升为1.308%),当归+桃仁+红花→川芎(支持度16.25%,提升为1.758%),天竺黄→丹参(支持度17.75%,提升1.736%),竹茹→红花(支持度15%,提升1.199%),竹茹→丹参(支持度15%,提升1.514%),赤芍+红花→桃仁(支持度25.5%,提升度1.433),赤芍+川芎→红花(支持度17.25%,提升度1.237%),桃仁→红花(支持度为54.75%,提升度为1.269%),川芎+桃仁→红花(支持度为22%,提升度为1.388%),牛膝+红花→桃仁(支持度为15%,提升度为1.492%)等。结论:关联规则可用于脑梗死恢复期血瘀质药物的配伍规律研究,活血化瘀药与其他药物配伍是临床用药关键。
[Abstract]:Objective: to analyze the regularity of drug use in convalescent patients with cerebral infarction with blood stasis by using association rules, and to provide reference for clinical prevention and treatment. Methods: according to the epidemiological investigation method, Shandong traditional Chinese Medicine Hospital and Yantai traditional Chinese Medicine Hospital were selected. Penglai traditional Chinese Medicine Hospital and other different regions and different levels of three Chinese medicine hospitals in the convalescent stage of cerebral infarction patients with blood stasis, collect their prescriptions, using SPSS Clementine 12.0 data mining software to the data contained in the association rules mining research. Results: in this study, 400 prescriptions with 242 Chinese herbs were obtained. There are 49 kinds of drugs that have been used more than 25 times (including 25 times). The first five drugs used frequently are blood activating drugs, tonifying drugs, heat clearing drugs, phlegm relieving cough and relieving asthma medicine, calming the liver and relieving wind medicine. A total of 250 rules have been obtained. The most common drug is safflower, followed by peach kernel, angelica sinensis, ligustraum chuanxiong, red peony etc. Among them, the rule with higher support degree is: licorice safflower. 鈫扨each kernel (supporting degree 23.00, promoted to 1.39 Rhizoma Rhizoma Chuanxiong). 鈫扴afflower (supporting degree 18.75, promoted to 1.227%), Angelica sinensis. 鈫扨each kernel (support degree 20. 5%, promoted to 1. 448%), Angelica sinensis. 鈫扲hizoma Chuanxiong (support degree 20.5g, promoted to 1.7cm, Safflower Atractylodes. 鈫扨each kernel (support degree 18. 5%, promoted to 1. 308%), Angelica sinensis red flower. 鈫扲hizoma Chuanxiong (supporting degree 16.25), promoted to 1.758 Rhizome, Tianzhu Huang. 鈫扴alvia miltiorrhiza (support degree 17.75), raise 1.736%, Bamboo Ru. 鈫扴afflower (support degree 15, lift up 1.199). 鈫扴alvia miltiorrhiza (support degree 15, promotion 1.514), red peony safflower. 鈫扨each seed (supporting degree 25.5, lifting degree 1.433), Rhizoma Chuanxiong Rhizoma Paeoniae Alba. 鈫扴afflower (support 17.25), lifting 1.237am, peach kernel. 鈫扴afflower (support is 54.75, promotion is 1.269), Ligusticum chuanxiong (Peach kernel). 鈫扴afflower (support is 22g, promotion is 1.388b), Achyranthes bidentata. 鈫扖onclusion: Association rules can be used to study the compatibility of blood stasis drugs in the convalescent period of cerebral infarction, and the compatibility of promoting blood stasis drugs with other drugs is the key to clinical use.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7;TP311.13

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