紫贝止咳颗粒治疗急性气管-支气管炎的多中心临床观察

发布时间：2018-02-22 10:22

本文关键词： 紫贝止咳颗粒余邪恋肺证急性气管-支气管炎　出处：《中成药》2017年10期 　论文类型：期刊论文

【摘要】：目的评价紫贝止咳颗粒(紫菀、矮地茶、川贝,等)治疗急性气管-支气管炎(余邪恋肺证)的5家医院临床观察及安全性。方法采取随机、双盲双模拟、阳性平行对照的临床研究方法。240例患者按1∶1的比例分为试验组与对照组,试验组口服紫贝止咳颗粒,对照组口服止咳宝片(紫菀、橘红、桔梗,等),治疗5 d。结果全分析集(full analysis set,FAS)分析人群,紫贝止咳颗粒治疗急性气管-支气管炎疗效总有效率为73.04%,对照组为54.78%,两组总有效率比较差异有统计学意义(P0.01),中医证候总有效率试验组为73.91%;对照组为60.86%。两组总有效率比较差异有统计学意义(P0.05),对咳嗽、咯痰单项症状的改善试验组优于对照组。结论紫贝止咳颗粒治疗急性气管-支气管炎(余邪恋肺证),具有良好的临床疗效。
[Abstract]:Objective to evaluate the clinical observation and safety of Zibei Zhike granule (Aster, tea, Chuanbei, et al) in the treatment of acute tracheobronchial bronchitis. Methods of clinical study of positive parallel control. 240 patients were divided into experimental group and control group according to the ratio of 1: 1. The experimental group took Zibei Zhike granule and the control group took Zhikebao tablets (Aster, orange red, Platycodon grandiflorum). Results full analysis set FASA was used to analyze the population. The total effective rate of Zibei Zhike granule in the treatment of acute trachea-bronchitis was 73.04, and that in the control group was 54.78. The difference between the two groups was statistically significant (P 0.01), the total effective rate of TCM syndrome was 73.91% in the experimental group and 60.86% in the control group. The total effective rate of the two groups was 60.86. The difference in rate was statistically significant (P 0.05). Conclusion the treatment of acute trachea bronchitis with Zibei Zhike granule has good clinical effect.
【作者单位】：河南省中医药研究院;河南中医学院;湖南中医药大学第一附属医院;四川大学华西医院;长春中医药大学附属医院;吉林省中西医结合医院;
【基金】：河南省中医临床学科领军人才培养计划(1403522)
【分类号】：R259

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