苦梅散熏洗治疗趾间糜烂型足癣（湿热下注证）的临床疗效观察

发布时间：2018-02-23 00:02

本文关键词： 趾间糜烂型足癣苦梅散熏洗疗法临床观察　出处：《成都中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：通过与0.5%聚维酮碘溶液进行临床观察对比,初步探讨和评价苦梅散熏洗治疗趾间糜烂型足癣的疗效及安全性,为趾间糜烂型足癣提供一个安全、有效的治疗方案。方法：通过查随机数字表,将70例合格受试者随机分配到治疗组(35例)和对照组(35例)。治疗组采用苦梅散熏洗治疗,对照组采用0.5%聚维酮碘溶液浸泡治疗,疗程均为2周。以皮损面积、浸渍、糜烂、渗出及瘙痒程度为临床观察指标,以真菌镜检结果为病原学观察指标。对两组患者在治疗前、治疗第7天、治疗第14天及治疗结束4周后的病情予以观察并评分,判定疗效及安全性。所有观察数据均采用SPSS21.0进行统计学分析。结果：(1)完成临床研究病例共65例。治疗组32例,对照组33例。治疗组痊愈率59.38%,愈显率81.25%,真菌清除率81.25%；对照组痊愈率51.52%,愈显率69.70%,真菌清除率84.85%。两组综合疗效及真菌学疗效相当(P均0.05)。(2)治疗第7天,治疗组皮损面积、浸渍、渗出及瘙痒程度的改善均优于对照组(P均0.05)。(3)治疗第14天,治疗组在浸渍、渗出及瘙痒程度方面较对照组有明显改善(P均0.05),其中浸渍程度的改善有显著性差异(P0.01)。(4)复发率方面,治疗组复发率10.53%,对照组复发率17.65%,P0.05,无明显差异。结论：(1)通过对两组患者的综合疗效及真菌学疗效进行临床观察对比,发现苦梅散熏洗疗法具有较好的抗炎、止痒、抗真菌作用,其疗效与0.5%聚维酮碘溶液浸泡疗法相当。(2)苦梅散熏洗疗法起效较快,能够尽早的治疗和缓解患者的临床不适感,对趾间糜烂型足癣患者的浸渍、渗出及瘙痒程度的改善优于0.5%聚维酮碘溶液。(3)苦梅散熏洗治疗趾间糜烂型足癣安全性较好,在治疗过程中未见任何不良反应,值得临床推广应用。
[Abstract]:Objective: to explore and evaluate the efficacy and safety of Kumei Powder fumigation and washing in the treatment of interphalangeal erosive tinea pedis by clinical observation and comparison with 0.5% povidone iodine solution, so as to provide a safety for the treatment of intertoe erosive tinea pedis. Methods: 70 eligible subjects were randomly assigned to the treatment group (35 cases) and the control group (35 cases). The treatment group was treated with Kumei powder fumigation and the control group was treated with 0.5% povidone iodine solution. The course of treatment was 2 weeks. The lesion area, maceration, erosion, exudation and pruritus were taken as the clinical observation indexes, and the results of fungal microscopy were taken as the pathogenic indexes. The patients in the two groups were treated on the 7th day before treatment. On the 14th day of treatment and 4 weeks after treatment, the patients were observed and scored, and the efficacy and safety were evaluated. All the observed data were statistically analyzed by SPSS21.0. Results 65 cases of clinical study were completed in the treatment group, 32 cases in the treatment group, 32 cases in the treatment group, and 32 cases in the treatment group. There were 33 cases in the control group. The cure rate in the treatment group was 59.38%, the recovery rate was 81.25%, the fungal clearance rate was 81.25%; in the control group, the cure rate was 51.522%, the effective rate was 69.70%, and the fungal clearance rate was 84.85%. The improvement of the degree of exudation and pruritus was better than that of the control group (P < 0.05). On the 14th day of treatment, the degree of dipping, exudation and pruritus in the treatment group was significantly improved than that in the control group (P < 0.05), and there was significant difference in the improvement of the degree of dipping (P < 0.01). The relapse rate of the treatment group was 10.53, while that of the control group was 17.65g / P0.05.ConclusionThe comprehensive curative effect and mycological effect of the two groups were observed and compared, and it was found that Kumei Powder fumigation and washing therapy had better anti-inflammatory, anti-itch and anti-fungal effects. The curative effect is similar to that of 0.5% povidone iodine solution soaking therapy) Kumei Powder fumigation and washing therapy can treat and relieve the clinical discomfort of the patients as early as possible, and impregnate the patients with the type of foot of interphalangeal erosion, the curative effect is similar to that of 0.5% povidone iodine solution soaking therapy. The improvement of exudation and pruritus was better than that of 0.5% povidone iodine solution.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R275.9

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