内异停方对巧克力囊肿患者临床疗效及Foxp3因子的干预研究

发布时间：2018-02-23 00:37

本文关键词： 子宫内膜异位症内异停方腹腔镜 Foxp3因子　出处：《南京中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：通过观察巧克力囊肿患者经腹腔镜术前、术后联合中药治疗与单纯行腹腔镜术后异位内膜中Foxp3因子的阳性表达、临床症状及中医证候的改善情况,初步探讨中药对子宫内膜异位症的治疗机理,以求多方面为中医治疗本病提供理论思路,为中西医结合治疗内异症供给更多客观科学依据,为内异症患者提供更加规范标准的方案,从而使得中医药治疗内异症的成效全面提高。方法：以随机对照原则,按1：1的比例,将研究对象,即2014年12月至2015年10月入住江苏省中医院的被确诊为巧克力囊肿的40例患者分为两组。实验组于术前3个月及术后6个月连续服用中药内异停,月经期停药；对照组只进行腹腔镜微创治疗。术前及术后分别对两组患者进行安全性、疗效性指标观察及特殊指标的比较,统计分析两组患者术中异位内膜Foxp3因子表达情况及临床症状、中医证候、复发率及一般资料之间的差异。结果：两组各20例,无脱落病例。两组一般情况比较,差异不显著(P0.05);术后6个月两组的①异位内膜Foxp3阳性表达情况比较,P=0.0030.05,差异显著；②中医症候评分比较,治疗指数比较,CA125水平比较,以及复发率比较,P值均0.05,差异显著,有统计学意义。结论：1.内异停方对患者异位内膜上Foxp3因子的表达具有抑制作用,实验组与对照组差异显著,效果确切。2.内异停方能有效改善患者相关临床症状,减轻痛经、月经紊乱等痛苦,减少复发率。
[Abstract]:Objective: to observe the positive expression of Foxp3 factor in ectopic endometrium of patients with chocolate cyst before and after laparoscopy combined with traditional Chinese medicine treatment and simple laparoscopy, and to observe the improvement of clinical symptoms and syndromes of traditional Chinese medicine. To explore the therapeutic mechanism of traditional Chinese medicine for endometriosis, in order to provide theoretical ideas for TCM treatment of endometriosis, and provide more objective scientific basis for the treatment of endometriosis by integrated Chinese and western medicine. To provide a more standardized scheme for patients with endometriosis, so as to improve the effectiveness of traditional Chinese medicine in the treatment of endometriosis in an all-round way. Methods: according to the principle of random control, according to the ratio of 1: 1, the subjects will be studied. From December 2014 to October 2015, 40 patients admitted to Jiangsu Provincial Hospital of traditional Chinese Medicine were divided into two groups. The patients in the control group were treated with laparoscopic minimally invasive therapy. Before and after operation, the safety, efficacy and special indexes were observed and compared, and the expression of Foxp3 factor and clinical symptoms of ectopic endometrium in the two groups were statistically analyzed. The difference between TCM syndromes, recurrence rate and general data. Results: there were 20 cases in each group, and there were no cases of abscission. The general conditions of the two groups were compared. There was no significant difference between the two groups in the expression of Foxp3 in ectopic endometrium (P 0.0030.05), there was significant difference in TCM symptom score, treatment index, and recurrence rate (P = 0.05), the difference was significant (P < 0.05), and there was no significant difference between the two groups in the expression of Foxp3 in ectopic endometrium at 6 months after operation, the difference was significant in the scores of TCM symptoms, the therapeutic index and the recurrence rate (P = 0.05). Conclusion: 1. Neiyitu decoction can inhibit the expression of Foxp3 factor on ectopic endometrium, and the difference between experimental group and control group is significant. 2. Neiyidu decoction can effectively improve the clinical symptoms of patients and relieve dysmenorrhea. Menstrual disorder and other pain, reduce recurrence rate.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R271.9

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