基于泛髓关系的骨质疏松症和中风后遗症治疗用方关联性分析

发布时间：2018-02-26 13:09

本文关键词： 骨质疏松症中风后遗症泛髓关系中医药治疗　出处：《山东中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:基于泛髓关系假说,探讨骨质疏松症和中风后遗症的治疗处方关联性,从而为髓病的治疗体系构建提供有益参考。方法:收集整理2006-2015年间治疗骨质疏松症和中风后遗症的经验处方,建立数据库,运用中医传承辅助系统分析治疗两类疾病的药物使用规律。结果:在治疗骨质疏松症及中风后遗症的前50味高频率药物中,有35味药物重合,分别为白芍、白术、川芎、丹参、胆南星、当归、党参、地龙、杜仲、茯苓、甘草、葛根、枸杞子、骨碎补、龟甲、何首乌、红花、黄芪、鸡血藤、僵蚕、龙骨、牡蛎、牛膝、全蝎、人参、山药、山茱萸、蛇床子、生地黄、石菖蒲、熟地黄、水蛭、天麻、菟丝子、蜈蚣。在治疗骨质疏松症及中风后遗症的前25味高频率药物中,有9味药物重合,分别为白芍、白术、丹参、当归、茯苓、甘草、黄芪、牛膝、熟地黄。同时,两者治疗药物的性味归经也极为相似,治疗骨质疏松症所用的药物中,以温性药物为主,其次为平、寒;以甘味药物为主,其次为苦、辛;以入肾经、肝经为主,其次为脾经、心经;在治疗中风后遗症所用药物中,以温性药物为主,其次为寒、平;以甘味药物为主,其次为辛、苦;以入肝经、肾经、脾经为主,其次为心经。骨质疏松症组核心药物有熟地黄,牛膝、淫羊藿,续断、黄芪、杜仲、补骨脂、骨碎补、山药。中风后遗症组核心药物有当归、黄芪、川芎、红花、桃仁。在常用药对及三味药组合方面,骨质疏松组侧重补益肝肾,而中风后遗症组则侧重补血和益气活血。结论:骨质疏松症与中风后遗症的中药治疗均注重补益气血和活血,药味均以甘、苦、辛为主,药性以温为主,归经以肝肾为主,提示这可能是“泛髓关系”中各类髓病的共有用药规律之一;同时,由于当前中风后遗症的治疗多倾向从气血论治,尚未从髓的角度加以系统总结和探讨,而骨质疏松所体现出的髓病治疗用药规律恰可以为中风后遗症的治疗提供新思路,且已初步展示出良好应有前景,有待于进一步研究。
[Abstract]:Objective: to explore the relationship between the prescription of osteoporosis and the sequelae of apoplexy based on the hypothesis of panmedullary relationship. Methods: collecting and sorting out the experience prescriptions of treating osteoporosis and stroke sequelae from 2006 to 2015, establishing a database, Results: among the first 50 high-frequency drugs for the treatment of osteoporosis and apoplexy sequelae, 35 kinds of drugs were superimposed, namely Radix Paeoniae Alba, Radix Atractylodes macrocephala, Rhizoma Chuanxiong, Salvia miltiorrhiza, and Radix Salviae Miltiorrhizae. South Star of gallbladder, Angelica sinensis, Codonopsis, Dilong, Eucommia, Poria, Glycyrrhiza, Radix Puerariae, Fructus Lycii, Fructus Distilla, Turtle, Polygonum multiflorum, Carthamus, Astragalus, Chicken Rattan, Silkworm, Silkworm, Oyster, Oyster, Achyranthes bidentata, Scorpio, Ginseng, yam, Cornus, Cnidium cnidii, Rehmannia, Acorus calamus, Rehmannia Rehmanniae, Leech, Gastrodia elata, Cuscuta, Centipede. In the first 25 high-frequency drugs for treating osteoporosis and apoplexy sequelae, there are 9 kinds of drug superposition: Radix Paeoniae Alba, Radix Atractylodis macrocephalae, Salvia miltiorrhiza, Radix angelicae Sinensis, Poria cocos, licorice, astragalus, Achyranthes bidentata and Rehmannia glutinosa. At the same time, the quality of the drugs used for treating osteoporosis is also very similar. The second is bitter, the second is bitter; the second is the kidney meridian, the liver meridian is the main, the second is the spleen meridian, the heart meridian; in the treatment of the sequelae of apoplexy, the main medicine is the warm drug, the second is the cold, and the other is the cold, the ping; the sweet medicine is the main medicine, the second is the Xin, bitter; and the liver meridian, Kidney Meridian, spleen Meridian is dominant, followed by Heart Meridian. The core drugs in osteoporosis group are Radix Rehmanniae, Achyranthes bidentata, Herba Epimedii, Dipsacus, Astragalus, Eucommia ulmoides, Psoralen, BMD, Chinese yam. The core drugs in the apoplexy group are Angelica sinensis, Astragalus membranaceus, Ligusticum chuanxiong. Safflower, peach kernel. In the combination of common medicine and three kinds of medicine, the osteoporosis group focuses on tonifying the liver and kidney, Conclusion: the traditional Chinese medicine treatment of osteoporosis and apoplectic sequelae all pay attention to replenishing qi and promoting blood circulation, the medicine taste is mainly sweet, bitter, and Xin, the medicine is mainly warm, and the meridian is mainly liver and kidney. It is suggested that this may be one of the common drug rules of various myelopathy in the panmedullary relationship, and at the same time, because the current treatment of apoplexy sequelae tends to be based on the treatment of qi and blood, it has not been systematically summarized and discussed from the point of view of pulp. The treatment of myelopathy reflected by osteoporosis can provide a new idea for the treatment of apoplexy sequelae, and has shown a good prospect, which needs further study.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R255.2

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