糖参乐丸治疗2型糖尿病（气阴两虚证）的临床疗效观察

发布时间：2018-02-28 23:06

本文关键词： 糖尿病气阴两虚证糖参乐丸临床观察　出处：《湖北中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:本研究旨在通过临床观察糖参乐丸治疗2型糖尿病(气阴两虚证)的临床疗效及其安全性,证明糖参乐丸是治疗此类型糖尿病的有效药物,为临床治疗该病提供一定参考依据。方法:收集2015年6月一2016年6月就诊于荆州市中医医院内分泌的78例气阴两虚型诊断为2型糖尿病患者,并将其随机划分为治疗组和对照组,治疗组39例,对照组39例,比较两组患者的性别、年龄、病程、体质指数、病情严重程度以及中医证候总积分等各个方面,两组并无明显差异,具有可比性(P0.05)。对照组口服二甲双胍缓释片,每次0.5g,每日3次,饭后服用;治疗组在上述治疗基础上加予口服糖参乐丸,每次6g,每日3次,饭前服用。两组治疗均以3个月为1个疗程。观察指标为治疗前后两组患者的症状积分、空腹血糖及餐后2小时血糖、糖化血红蛋白、血脂情况。结果:治疗前后两组患者的中医症状总积分皆有显著性差异(P0.05),且治疗组疗效优于对照组(P0.05)。治疗组总有效率为89.7%,对照组总有效率为74.4%,治疗组的临床总有效率亦高于对照组(P0.05)。治疗组能够明显改善患者的口渴喜饮、倦怠乏力等主要症状,对多食善饥、多尿、气短懒言等次要症状也有改善,且效果更优于对照组。两组患者在治疗前后的主症、次症疗效积分方面均有显著的差别(P0.05)。两组均能有效降低患者的空腹血糖及餐后2小时血糖、糖化血红蛋白、血脂指标,统计结果显示治疗组的降低程度大于对照组(P0.05)。结论:本研究结果提示糖参乐丸能有效治疗2型糖尿病(气阴两虚证),改善患者的临床症状及相关实验室指标,其疗效优于西药组,且价格适中,便于携带服用,为中医中药治疗糖尿病提供了有效可行的方法。
[Abstract]:Objective: to observe the clinical efficacy and safety of Tangshenle Pill in the treatment of type 2 diabetes mellitus (deficiency of Qi and Yin), and to prove that Tangshenle Pill is an effective drug for the treatment of this type of diabetes. Methods: 78 cases of type 2 diabetes diagnosed by deficiency of Qi and Yin were collected from June 1st 2015 to June 2016 in Jingzhou Hospital of traditional Chinese Medicine. They were randomly divided into treatment group and control group, 39 cases in treatment group and 39 cases in control group. The sex, age, course of disease, body mass index, severity of illness and total score of TCM syndromes were compared between the two groups. There was no significant difference between the two groups (P 0.05). The control group took metformin sustained-release tablets at 0.5 g, 3 times a day, after meals. The treatment group was treated with Tangshenle pills, 6 g per day, 3 times a day, on the basis of the above treatment. Taken before meals. The two groups were treated with 3 months as a course of treatment. The observation indexes were the symptom score, fasting blood glucose, 2 hours postprandial blood glucose, glycosylated hemoglobin, and hemoglobin glycosylated in the two groups before and after treatment. Results: there were significant differences in the total scores of TCM symptoms between the two groups before and after treatment, and the curative effect of the treatment group was better than that of the control group (P 0.05). The total effective rate of the treatment group was 89.7%, the total effective rate of the control group was 74.4%, and the clinical efficacy of the treatment group was 74.4%. The efficiency of the treatment group was also higher than that of the control group (P 0.05). The main symptoms, such as burnout and fatigue, also improved the secondary symptoms, such as polyfood and hunger, polyuria, shortness of breath and lazy speech, and the effect was better than that of the control group. There were significant differences in the scores of the secondary symptoms (P 0.05). The fasting blood glucose, 2 hours postprandial blood glucose, glycosylated hemoglobin and blood lipid were significantly decreased in the two groups. The statistical results showed that the degree of decrease in the treatment group was greater than that in the control group (P 0.05). Conclusion: this study suggests that Tangshenle pills can effectively treat type 2 diabetes mellitus (qi and yin deficiency syndrome) and improve the clinical symptoms and related laboratory indexes of the patients. Its curative effect is superior to the western medicine group, and the price is moderate, easy to carry and take, which provides an effective and feasible method for the treatment of diabetes mellitus with traditional Chinese medicine.
【学位授予单位】：湖北中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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