基于多个基因的多态性角度对老年男性骨质疏松症肾虚证的形成机制研究

发布时间：2018-03-01 00:16

本文关键词： 骨质疏松症肾虚证基因　出处：《浙江中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的比较在老年男性肾虚证群体中,骨质疏松症患者和对应骨质正常者的VDR、AR、CYP19以及EN1基因的基因型差异。方法从我院回顾性的纳入100名老年男性骨质疏松症肾虚证患者,100名年龄对应的骨质正常肾虚证患者。采用逻辑回归的方法比较基因型的差异。结果发现VDR、AR及CYP19的基因型在骨质疏松症肾虚证患者和骨质正常人群中存在显著的分布差异。结论此实验结果证实了老年男性骨质疏松症肾虚证患者和骨质正常肾虚证患者中基因型存在显著的分布差异,证实了维生素D、性激素以及EN-1等可影响早起生长发育的基因在骨质疏松症发病中的作用,并且将研究人群限制在男性肾虚症患者,通过中西医结合的角度解释了骨质疏松症的发病机制,对今后在发病原因及治疗的研究提供了新的角度。
[Abstract]:Objective to compare the prevalence of kidney deficiency in elderly men. The genotypes of CYP19 and EN1 gene in osteoporosis patients and those corresponding to normal bone were compared. Methods 100 aged male patients with kidney deficiency syndrome of osteoporosis and 100 age-matched patients with normal kidney deficiency syndrome were retrospectively included in our hospital. The results showed that VDR AR and CYP19 genotypes were significantly different in osteoporosis patients with kidney deficiency syndrome and bone normal population. Conclusion the results of this study confirm that VDR AR and CYP19 genotypes are significantly different between the patients with kidney deficiency syndrome and those with normal bone. There were significant differences in the distribution of genotypes between the aged male patients with kidney deficiency syndrome and those with normal kidney deficiency syndrome. It has confirmed the role of vitamin D, sex hormone and EN-1 in the pathogenesis of osteoporosis, and limited the study population to male kidney deficiency patients. The pathogenesis of osteoporosis was explained from the angle of integration of traditional Chinese and western medicine, which provided a new perspective for the study of the etiology and treatment of osteoporosis in the future.
【学位授予单位】：浙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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