复方丹参注射液对于新生儿缺氧缺血性脑病的疗效以及血清Tau蛋白对其评价的临床意义

发布时间：2018-03-02 03:29

本文关键词： 复方丹参注射液 Tau蛋白新生儿缺氧缺血性脑病酶联免疫吸附试验(ELASA)　出处：《辽宁中医杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的:探讨新生儿缺氧缺血性脑病(HIE)患儿血清Tau蛋白水平的变化,以及采用复方丹参注射液治疗HIE的过程中Tau水平监测对于疗效监测的临床价值。方法:选择新生儿HIE 60例,随机分为观察组和对照组,对照组采用常规治疗,观察组在常规治疗的基础上采用复方丹参注射液治疗,于治疗前、治疗第3、7、10、14、21、28天分别进行NBNA评分及血清Tau蛋白水平检测,对比两组之间的治疗效果、不同治疗时期Tau检测结果,并分析不同治疗时期Tau检测结果与NBNA评分的相关性。结果:观察组的患儿在症状缓解、惊厥消失、住院病程等方面的指标均明显优于对照组患儿,获得较为明显的治疗效果。治疗前及治疗第3天两组患儿的Tau检测结果无统计学差异(P0.05),自治疗第3天起至疗程结束日,观察组的Tau均显著低于对照组(P0.01);Tau浓度与NBNA评分呈现出显著负相关(P0.05)。结论:Tau水平测定可作为协助判断HIE患儿的脑损伤程度及评价复方丹参注射液治疗效果的临床指标。
[Abstract]:Objective: To explore the neonatal hypoxic-ischemic encephalopathy (HIE) changes in protein levels of serum Tau, Tau levels and the monitoring process of Compound Danshen injection in the treatment of HIE clinical value for monitoring the therapeutic effect. Methods: 60 cases of neonatal HIE, were randomly divided into observation group and control group, the control group received routine treatment, in the observation group on the basis of routine treatment with Compound Danshen injection treatment, before treatment, treatment after 3,7,10,14,21,28 days were detected NBNA score and serum levels of Tau protein, compared the therapeutic effect between the two groups, with treatment period of Tau test results, and analyze the correlation between the detection results of different treatment periods of Tau and NBNA score. Results: in the observation group the children in the remission of symptoms, convulsions disappear, the duration of hospitalization and other indicators were significantly better than the control group, obtained obvious treatment effect before and after treatment. The third day of the two groups of children Tau detection showed no statistically significant difference (P0.05), since third days of treatment to the end of the treatment, the observation group Tau were significantly lower than the control group (P0.01); Tau concentration and NBNA score showed a significant negative correlation (P0.05). Conclusion: the Tau level can be used as a clinical index to determine the the effect of Compound Danshen injection in the treatment of brain injury and evaluation of children with HIE.

【作者单位】：邢台市人民医院新生儿科;
【基金】：邢台市科技计划项目(2015ZC069)
【分类号】：R272

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