冠心病稳定型心绞痛患者血清白介素-6水平与中医证候要素痰、瘀的相关性研究

发布时间：2018-03-03 09:15

本文选题：冠心病　切入点：白介素-6　出处：《南京中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：探讨冠心病稳定型心绞痛血清白介素-6水平与中医证候要素痰、瘀的相关性,为冠心病中医辨证提供更多客观化依据。方法：临床搜集确诊为冠心病稳定型心绞痛患者病例122例,对患者中医证候要素积分进行统计,并测量患者血清白介素-6水平,通过2X2析因分析,研究血清白介素-6水平与中医证候要素痰、瘀之间的相关性。结果：白细胞介素-6水平,在冠心病有“痰”组,明显高于无“痰”组(P=0.00)；有“瘀”组,明显高于无“瘀”组(P=0.00)；“痰瘀互结”组,明显高于“非痰非瘀”组(P=0.00)；“痰瘀互结”组,明显高于“痰浊”组(P值=0.00)；“痰瘀互结”组,明显高于“瘀血”组(P值=0.005)；“痰浊”组,明显高于“非痰非瘀”(P值=0.002)。白细胞介素-6水平与痰证、瘀证积分高度正相关。白细胞介素-6水平与痰证证素积分存在线性回归关系；与瘀证证素积分存在曲线回归关系。结论：1.冠心病患者血清白细胞介素-6水平,在痰、瘀两个证候要素上密切相关。当痰瘀两种证候要素兼夹存在时,白细胞介素-6的水平,于痰、瘀两种病理因素共存情况下,明显高于两种病理因素皆无,或仅有一种病理因素作祟时。2.冠心病患者血清白细胞介素-6水平,在“瘀血”组,与“痰浊”组比较,两组间不存在显著统计学差异。两者鉴别诊断方向还需要进一步研究。
[Abstract]:Objective: To investigate the stable angina pectoris of coronary heart disease serum interleukin -6 levels and TCM Syndromes of phlegm, blood stasis and correlation, provide more objective basis for TCM syndrome differentiation of coronary heart disease. Methods: to collect clinical cases diagnosed in patients with stable angina pectoris of coronary heart disease in 122 cases, statistics of syndromes elements integral, and measurement of serum interleukin -6 levels by 2X2 factorial analysis of serum interleukin -6 levels and TCM Syndromes of phlegm and blood stasis. Results: the correlation between interleukin -6 levels in coronary heart disease group was significantly higher than that of "phlegm", no "sputum" group (P=0.00); the "stasis" group, obviously no higher than the "stasis" group (P=0.00); the phlegm and blood stasis group, was significantly higher than that of non phlegm and non blood stasis group (P=0.00); the phlegm and blood stasis group, was significantly higher than that of "phlegm" group (P =0.00); the phlegm and blood stasis group was significantly higher than that of "blood stasis" ("group The value of P =0.005); "phlegm" group was significantly higher than that of "non Sputum Stasis" (P = =0.002). Interleukin -6 level and phlegm syndrome, blood stasis syndrome integral high positive correlation integral interleukin -6 level and phlegm syndrome had linear regression relation with blood stasis syndrome; there exists a integral curve regression relationship. Conclusion: 1. the serum interleukin -6 level in sputum, blood stasis two syndrome elements are closely related. When the two kinds of phlegm and blood stasis syndrome elements and clip exist, interleukin -6 level in sputum, blood stasis two kinds of pathological factors coexist situation that is obviously higher than that of two kinds of pathological factors are, or only a pathological factor.2. in serum of patients with coronary heart disease and interleukin -6 levels in blood stasis group, compared with the "phlegm" group, no significant difference existed between the two groups. Further research is needed both differential diagnosis.

【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

【相似文献】