血必净注射液对脓毒症的临床疗效以及对血清炎症因子水平和血液流变学的影响

发布时间：2018-03-03 18:20

  本文选题：脓毒症　切入点：血必净注射液　出处：《中华中医药学刊》2017年09期 　论文类型：期刊论文

【摘要】：目的:研究血必净注射液对脓毒症的临床疗效以及对血清炎症因子水平和血液流变学的影响,为临床诊疗提供依据。方法:脓毒症患者60例,根据数字表法均分为两组,观察组(30例)和对照组(30例),对照组患者给予常规的治疗方案,观察组在对照组的基础上加用血必净注射液治疗,比较两组患者治疗前、治疗3 d后的白细胞水平、体温等临床治疗效果,以及治疗前后血清降钙素原(PCT)、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白介素6(IL-6)等炎症因子和平均动脉压(MAP)、中心静脉压(CVP)等血液流变学之间的差异情况。结果:观察组患者白细胞水平(7.8±0.5)×109/L、平均体温(36.7±0.2)℃,明显优于对照组患者治疗后的白细胞水平(13.6±0.5)×109/L、平均体温(37.8±0.2)℃,两组差异比较有统计学意义;观察组患者PCT(2.16±0.21)μg/L、CRP(11.3±1.9)μg/L、TNF-α(11.8±2.0)pg/m L、IL-6(52.7±2.7)pg/m L,明显优于对照组患者治疗后的平均心率PCT(3.24±0.28)μg/L、CRP(17.8±2.0)μg/L、TNF-α(19.6±2.2)pg/m L、IL-6(73.9±2.6)pg/m L,两组差异比较有统计学意义(P0.05);观察组患者平均心率(99.6±2.3)次/分、平均动脉压(70.8±3.0)mm Hg、中心静脉压(6.7±0.2)mm Hg,明显优于对照组患者治疗后的平均心率(113.6±2.5)次/分、平均动脉压(62.6±2.6)mm Hg、中心静脉压(5.8±0.2)mm Hg,两组差异比较有统计学意义。结论:血必净注射液在脓毒症患者的应用中,具有较好的临床治疗效果,可以明显降低患者各项炎症因子水平,改善患者血液流变学状态,具有较好的临床应用效果,值得临床上进一步的借鉴和应用。
[Abstract]:Objective: to study the clinical effect of Xuebijing injection on sepsis and its effect on serum inflammatory factor level and hemorheology. Methods: sixty patients with sepsis were divided into two groups according to digital table method. Observation group (n = 30) and control group (n = 30). The patients in the control group were treated with routine treatment regimen, and the patients in the observation group were treated with Xuebijing injection on the basis of the control group. The leukocyte levels of the two groups were compared before and after treatment for 3 days. Body temperature and other clinical therapeutic effects, Before and after treatment, the differences of inflammatory factors, such as serum procalcitonin (PCT) C-reactive protein (CRP), tumor necrosis factor 伪 (TNF- 伪), interleukin-6 (IL-6), and mean arterial pressure (MAPP), central venous pressure (CVP), were compared. Results: the patients in the observation group were white. The cell level was 7.8 卤0.5 脳 10 9 / L, and the mean body temperature was 36.7 卤0.2 鈩，

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