敏肤煎冷敷治疗面部激素依赖性皮炎（风热证）的疗效观察

发布时间：2018-03-03 22:25

本文选题：敏肤煎　切入点：面部激素依赖性皮炎　出处：《成都中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：从症状、皮损及体征变化等方面观察、探讨敏肤煎冷敷治疗面部激素依赖性皮炎的临床疗效,分析此法可能的作用机理,比较该疗法两种不同处方的疗效,期望能进一步规范化、标准化中药外敷治疗面部激素依赖性皮炎的方法,以对面部激素依赖性皮炎的临床治疗提供更多的参考信息,发挥一定的临床作用。方法：本研究采用数字随机、对照的方法,将符合纳入标准、签署知情同意书的72例患者随机分为治疗组和对照组。治疗组采用敏肤煎冷敷治疗。对照组采用三黄洗剂加味冷敷患处。两组病患均口服黄莺教授治疗过敏性疾病的中药经验方免煎颗粒,疗程4周。观察治疗前后相应指标的改善情况。借助统计学软件SPSS17.0对各组资料进行统计分析,作出疗效判定及结果分析。结果：①两组治疗前后分别对红肿、灼热、瘙痒、鳞屑、皮损面积等观察指标的积分进行组内比较,各项指标积分比较P捚0.05,差异有统计学意义,说明两观察组对面部激素依赖性皮炎(风热证)在红肿、灼热、瘙痒、鳞屑、皮损面积等方面均有明显改善。②两组治疗后综合疗效组间比较,治疗组总有效率93.8%,对照组总有效率96.8%,P0.05,差异无统计学意义,说明两组综合疗效相当；③两组单项观察指标的疗效指数组间比较,瘙痒方面P=0.000.05,差异有统计学意义,说明敏肤煎在改善瘙痒方面优于三黄洗剂加味。皮损面积方面,对照组的变异系数大于对照组,认为对照组改善优于治疗组。红肿、灼热和瘙痒方面,P0.05,差异无统计学意义,说明两观察组对红肿、灼热、鳞屑等方面疗效无差异。④治疗组有1例未遵医嘱使用,自觉症状加重,嘱冷开水湿敷后缓解,继续使用无明显不良反应,说明敏肤煎外用安全可靠。结论：1、敏肤煎与三黄洗剂加味在治疗面部激素依赖性皮炎的红肿,灼热和鳞屑方面疗效相当。2、改善瘙痒方面,敏肤煎优于三黄洗剂加味：改善皮损面积方面三黄洗剂优于敏肤煎。3、敏肤煎短期疗效显著,药物价格低廉,操作方便,副作用小,值得在临床上推广和进一步研究。
[Abstract]:Objective: to investigate the clinical efficacy of Minfu decoction cold compress in treating facial hormone dependent dermatitis from the aspects of symptoms, lesions and signs, analyze the possible mechanism of this method, and compare the effects of two different prescriptions. We hope to further standardize and standardize the methods of external application of traditional Chinese medicine for the treatment of facial hormone dependent dermatitis, so as to provide more reference information for the clinical treatment of facial hormone dependent dermatitis. Methods: in this study, the digital randomized, controlled method will meet the inclusion criteria, 72 patients with informed consent were randomly divided into treatment group and control group. The treatment group was treated with Minfu decoction cold compress. The control group was treated with Sanhuang lotion plus modified cold compress. Diseased Chinese medicine experience prescription Fan-Fen granules, After 4 weeks of treatment, we observed the improvement of the corresponding indexes before and after treatment. The statistical software SPSS17.0 was used to analyze the data of each group, and the curative effect and the result were analyzed. Results before and after treatment, the two groups were treated with red swelling, burning heat, pruritus, and scales, respectively. The scores of the observed indexes, such as the area of skin lesion, were compared within the group, and the scores of the indexes were compared P 0.05, the difference was statistically significant, which indicated that the two groups had a significant difference in the treatment of facial hormone dependent dermatitis (wind-heat syndrome) in redness and swelling, burning heat, pruritus, scaly, and so on. The total effective rate of the treatment group was 93.8, the total effective rate of the control group was 96.8g / P 0.05, there was no significant difference between the two groups. It shows that the two groups have the same comprehensive curative effect and the curative effect index of the two groups is comparable. The pruritus is 0.000.05, the difference is statistically significant. It shows that Minfu decoction is better than Sanhuang lotion in improving itching. The area of skin lesion is better than that of Sanhuang lotion. The coefficient of variation of the control group was higher than that of the control group, and the improvement of the control group was better than that of the treatment group. There was no difference in the therapeutic effect of scale. 4 in the treatment group, 1 case did not follow the doctor's advice, the symptoms of the treatment group were aggravated, the cold and boiled water wet compress was ordered to relieve, and there was no obvious adverse reaction in the treatment group. ConclusionThe addition of Minfu decoction and Sanhuang lotion is effective in treating facial hormone dependent dermatitis, burning heat and scales, and improving pruritus, it is safe and reliable for external use of Minfu decoction, conclusion: 1: 1, Minfu decoction and Sanhuang lotion are effective in treating facial hormone dependent dermatitis. Minfu decoction is superior to Sanhuang lotion in improving the area of skin lesion. It is worth popularizing and further studying in clinic because of its obvious short-term curative effect, low price, convenient operation and small side effect.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R275.9

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