基于中医传承辅助系统的月经后期古代文献用药规律研究

发布时间：2018-03-04 09:32

本文选题：中医传承辅助系统　切入点：月经后期　出处：《山东中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:本研究通过对古代中医文献中与月经后期相关的中药、方剂,进行整理、总结、归类,探寻月经后期的基本理论及临床用药规律,包括组方规律,药物、药对及用药指征,并进行统计学分析,以期对月经后期及其引起的不孕症的治疗提供更好的思路和方法。方法:系统回顾古代中医文献,梳理出与月经后期有关的中药、方剂,筛选出有效方剂药物,建立月经后期方剂数据库,初步分析古代医家治疗月经后期及其相关症状的临床经验和常用方药。运用“中医传承辅助系统”,应用该软件的集成规则分析,改进互信息法、复杂系统熵聚类及无监督的熵层次聚类等数据挖掘方法[1],从整体上对月经后期的药物使用规律及配伍规律进行相关性分析。结果:通过中医传承辅助系统对治疗月经后期及其相关疾病的方剂进行药物频次、关联规则和复杂系统熵聚类的分析,综合结果可以得出其组方规律、常用药物、药对及用药指征。通过对古代文献中298首处方的分析,用药范围结果表明,共涉及215味中药,补虚药、活血化瘀药、理气药、温里药、利水渗湿药、化痰止咳平喘药、清热药等七类药物是月经后期最常用的药类。药物的四气分析结果显示:温性药物使用频率最高;药物五味分析结果显示甘味、辛味、苦味药物最常见;药物归经出现的频率由高到低的次序是:肝经、脾经、心经、肾经、肺经。利用“组方规律分析”版块,系统性分析常用药物及药对,并利用改进的互信息法进行药物关联性分析,形成34组常用药对,核心组合24个,基于无监督熵层次聚类法得出新方12个,并对新方中的核心药物进行分析,为临床临证处理及药物治疗提供理论依据。结论:本研究通过建立月经后期方药数据库,利用中医传承辅助系统对方剂进行录入、整理,从多方面、多角度进行分析,构建规范的证候、方药体系,对临床工作有重要指导意义,值得进一步推广应用。
[Abstract]:Objective: through sorting, summarizing and classifying the traditional Chinese medicine and prescriptions related to the late menstrual period in ancient Chinese medicine literature, to explore the basic theory and clinical drug use law of the late menstrual period, including the law of prescription and medicine. In order to provide a better idea and method for the treatment of postmenstrual period and infertility caused by it, a systematic review of the ancient Chinese medicine literature was carried out to sort out the Chinese medicine and prescription related to the late menstrual period. Screening out effective prescription drugs, establishing a database of prescriptions for late menstruation, A preliminary analysis of the clinical experience and common prescriptions of ancient physicians in the treatment of late menstruation and its related symptoms. By using the "Chinese Medicine inheritance Assistance system" and the application of the integrated rule analysis of the software, the mutual information method was improved. The methods of data mining such as entropy clustering and unsupervised entropy hierarchical clustering in complex systems [1] were used to analyze the correlation of drug use and compatibility in the later period of menstruation as a whole. Results: the treatment was treated by traditional Chinese Medicine (TCM) inheriting auxiliary system. The prescriptions for late menstruation and related diseases were used frequently. The association rules and entropy cluster analysis of complex systems can be used to find out the rule of its composition, common drugs, drug pairs and indications of drug use. By analyzing 298 prescriptions in ancient literature, the range of drug use shows that 215 kinds of traditional Chinese medicines are involved. Seven kinds of drugs, such as tonifying deficiency medicine, promoting blood circulation and removing blood stasis, regulating qi, warming medicine, promoting water and infiltrating dampness, resolving phlegm and relieving cough and relieving asthma, and clearing away heat, are the most commonly used drugs in the later period of menstruation. The results of four-gas analysis of the drugs show that: the use frequency of warm drugs is the highest; The results of the five-flavor medicine analysis showed that sweet taste, Xin flavor and bitter medicine were the most common drugs, and the frequency of the drug meridian appeared from high to low: liver, spleen, heart, kidney and lung. The common drugs and their pairs were systematically analyzed, and the improved mutual information method was used to analyze the drug association. 34 groups of common drug pairs were formed, with 24 core combinations, and 12 new drugs were obtained based on unsupervised entropy hierarchical clustering method. And the core drugs in the new prescription are analyzed to provide the theoretical basis for clinical clinical treatment and drug treatment. Conclusion: this study through the establishment of menstrual late prescription database, the use of traditional Chinese medicine inheritance assistance system for prescription input, collation, It is of great significance for clinical work to analyze from many aspects and angles, and to construct the standard syndrome and prescription system, which is worthy of further popularizing and applying.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R271.111

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