四妙痛风汤联合秋水仙碱治疗急性痛风性关节炎（湿热痹阻证）的临床研究

发布时间：2018-03-04 11:19

本文选题：急性痛风性关节炎　切入点：四妙痛风汤　出处：《河南中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:观察应用四妙痛风汤联合秋水仙碱治疗急性痛风性关节炎(湿热痹阻证)临床疗效,记录治疗前后实验室指标(BUA、CRP)的变化,通过对数据的对比分析,探讨四妙痛风汤联合秋水仙碱对急性痛风性关节炎的防治作用。方法:筛选自河南省中医院(河南中医药大学第二附属医院)风湿骨病科门诊的急性痛风性关节炎患者,证型为湿热痹阻证,60例,将采集到的病例随机分成治疗组和对照组,每组都是30例,各组全部进行医院正常的常规治疗,对照组的治疗方案为:口服秋水仙碱:1.0mg/次,2次/d。治疗组在此基础上加上四妙痛风汤,每日一剂,水煎服,早晚各200ml,由药房统一煎熬。两组都是七天一个疗程。记录收集两组患者1疗程治疗前后的临床症状评分、疗效及实验室指标BUA、CRP的数值,并进行统计分析。软件采用SPSS20.0软件包,所有结果均为计算机直接输出。结果:一疗程治疗后两组均取得了一定疗效。治疗组和对照组的总有效率分别为97.00%、90.00%。治疗组的总有效率要比对照组高,两组进行比较,差异无统计学意义(P0.05)。两组的症状积分在治疗前后都进行组内对比,结果显示都具有统计学意义(P0.05),两组治疗后在症状积分方面都有改善。两组的症状积分进行组间对比,治疗前进行对比无统计学意义(P0.05),治疗后进行对比具有统计学意义(P0.05),治疗组在改善临床症状评分要优于对照组。两组的BUA和CRP在治疗前后都进行组内对比,均具有统计学意义(P0.05),两组在治疗后BUA和CRP均有改善。两组BUA进行组间对比,治疗前两组的BUA对比无统计学意义(P0.05),治疗后两组的BUA对比结果显示具有统计学意义(P0.05),治疗组在BUA改善方面优于对照组。两组CRP组间对比,治疗前两组CRP对比无统计学意义(P0.05),治疗后两组CRP对比结果显示具有统计学意义(P0.05),治疗组在CRP改善方面优于对照组。结论:1、治疗组和对照组均能够减轻急性痛风性关节炎(湿热痹阻证)患者的临床症状,改善患者的血尿酸及C反应蛋白;2、治疗组在降低急性痛风性关节炎(湿热痹阻证)患者实验室指标(血尿酸、C反应蛋白)及改善临床症状方面优于对照组,值得临床推广应用。
[Abstract]:Objective: to observe the clinical efficacy of Simiao Tongfeng decoction combined with colchicine in the treatment of acute gouty arthritis (damp-heat arthralgia and obstruction syndrome), and to record the changes of laboratory index BUAP before and after treatment, and to compare and analyze the data. To explore the preventive and therapeutic effects of Simiao gout decoction combined with colchicine on acute gouty arthritis methods: the patients with acute gouty arthritis were selected from the Department of Rheumatology and Orthopedics Department of Henan traditional Chinese Medicine Hospital (the second affiliated Hospital of Henan University of traditional Chinese Medicine). There were 60 cases of dampness and heat obstruction syndrome. The collected cases were randomly divided into treatment group and control group, 30 cases in each group, all of which were treated with normal routine treatment in hospital. The treatment plan of the control group was oral colchicine: 1.0 mg / twice / d. On this basis, the treatment group added Simiao gout decoction, one dose daily, water decoction, In the morning and evening, 200 ml of each patient was subjected to unified suffering by the pharmacy. The two groups were treated with a course of treatment for seven days. The clinical symptom score, curative effect and the value of BUAN CRP before and after one course of treatment were recorded and analyzed in the two groups, and the software was analyzed by SPSS20.0 software package. Results: after a course of treatment, the two groups achieved certain curative effects. The total effective rates of the treatment group and the control group were 97.00 and 90.00.The total effective rate of the treatment group was higher than that of the control group, and the two groups were compared. The symptom scores of the two groups were compared before and after treatment. The results showed that there were significant differences in the symptom scores between the two groups after treatment, and the symptom scores of the two groups were compared between the two groups. There was no significant difference before treatment (P 0.05), but after treatment the comparison was statistically significant (P 0.05). The clinical symptom score of the treatment group was better than that of the control group. The BUA and CRP of both groups were compared before and after treatment. BUA and CRP were improved in both groups after treatment, and BUA was compared between the two groups. There was no significant difference in BUA between the two groups before treatment (P 0.05). The results of BUA comparison between the two groups were statistically significant after treatment. The improvement of BUA in the treatment group was better than that in the control group. There was no significant difference in CRP between the two groups before treatment (P 0.05). After treatment, the results of CRP contrast showed that there was significant difference between the two groups. The improvement of CRP in the treatment group was better than that in the control group. Conclusion: the treatment group and the control group can reduce the acute gouty. Clinical symptoms of patients with arthritis (damp-heat arthralgia syndrome), The treatment group was superior to the control group in reducing the laboratory index (blood uric acid C-reactive protein) and improving the clinical symptoms of the patients with acute gouty arthritis (damp-heat obstruction syndrome).
【学位授予单位】：河南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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