新发毒性弥漫性甲状腺肿患者日间功能、睡眠质量、心理稳定性变化分析

发布时间：2018-03-05 04:39

本文选题：毒性弥漫性甲状腺肿　切入点：心理稳定性　出处：《中华中医药杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的:探讨新发毒性弥漫性甲状腺肿(Graves)病患者日间功能、睡眠质量、心理稳定性的变化。方法:采用现况调研及病例对照研究方法,调查新发Graves病患者581例及健康对照800名。被调查者填写一般资料量表、愤怒郁怒体质调查表、匹兹堡睡眠质量指数量表(PSQI)、疲劳评定量表(FAI)。回收问卷,进行病例对照的多因素非条件Logistic回归分析。结果:多数新发Graves病患者日间功能差、睡眠质量下降、心理稳定性下降等发生的风险较大。心理稳定性下降发生风险存在性别差异,女性患者发生风险较大。睡眠质量下降表现在多维度,不同年龄、性别表现的维度不同。年龄大者表现为入睡所需时间延长,其发生风险度最大为健康对照组的1.235倍。不足30岁者仅在疲劳时心理稳定性下降。结论:Graves病为心身疾病,临床诊治时除典型症状外应注意患者有无日间功能障碍、睡眠质量下降、心理稳定性变差等,不同性别、年龄阶段问诊侧重点不同,针对不同症状给予相应的药物或心理治疗,以提高抗甲状腺药物治疗效果。
[Abstract]:Objective: to investigate the changes of daytime function, sleep quality and psychological stability in patients with new toxic diffuse goiter Graves disease. 581 newly diagnosed patients with Graves disease and 800 healthy controls were investigated. The respondents filled out general information scale, anger depression constitution questionnaire, Pittsburgh Sleep quality Index scale and fatigue rating scale. Multivariate conditional Logistic regression analysis was performed on the patients with Graves disease. Results: most of the newly diagnosed Graves patients had a higher risk of poor daytime function, lower sleep quality and lower psychological stability. Female patients are at greater risk. Sleep quality decline is manifested in multiple dimensions, different ages, different dimensions of gender performance. Older women show longer time to fall asleep. The maximum risk of the disease was 1.235 times of that of the healthy control group. The psychological stability of the patients under 30 years of age decreased only when they were tired. Conclusion: Graves disease is a psychosomatic disease. In clinical diagnosis and treatment, attention should be paid to whether the patients have daytime dysfunction except for typical symptoms. In order to improve the therapeutic effect of antithyroid drugs, the quality of sleep was decreased, the psychological stability became worse, and the emphasis of consultation was different in different gender and age stage, and the corresponding drugs or psychotherapy were given to different symptoms in order to improve the therapeutic effect of antithyroid drugs.
【作者单位】：济南市中心医院内分泌科;聊城市人民医院;山东中医药大学基础医学院;
【基金】：国家重点基础研究发展计划(973计划)项目(No.2006CB504800)~~
【分类号】：R259

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