丹溪痛风方治疗痰湿瘀阻型痛风性肾病的临床观察

发布时间：2018-03-06 00:19

本文选题：痛风性肾病　切入点：丹溪痛风方　出处：《黑龙江省中医药科学院》2016年硕士论文　论文类型：学位论文

【摘要】：目的:观察丹溪痛风方治疗痛风性肾病(痰湿瘀阻型)患者的临床疗效及安全性,初步探讨其作用机理,为临床治疗痛风性肾病提供安全有效的治疗药物。方法:将符合诊断及纳入标准的60例痛风性肾病患者分为急性期与慢性期两组,予以丹溪痛风方治疗。观察三个疗程(12周),观察治疗前后临床症状、体征、血尿酸(UA)、血肌酐(Scr)、尿素氮(BUN)、24小时尿蛋白定量(24hu-TP)等指标的变化,并将结果进行统计学分析比较。结果:1.两组治疗后临床疗效结果比较,慢性期组总有效率为90%,急性期组总有效率为80%。慢性期组优于急性期组,比较差异显著(P0.05)。2.两组治疗前后中医证候积分比较,有显著性差异(P0.05),且慢性期组优于急性期组。3.两组治疗前后血尿酸、24hu-TP比较,有显著性差异(P0.05),且慢性期组优于急性期组。4.肌酐、尿素氮、GHOL、TG与治疗前比较均明显降低,有显著性差异(P0.05)。5.两组治疗前后肝功能无明显变化,差异无统计学意义。结论:1.丹溪痛风方可有效改善急、慢性期痛风性肾病患者的临床症状和体征,但慢性期优于急性期。2.丹溪痛风方可明显降低急、慢性期痛风性肾病患者UA、BUN及血脂,有效减少痛风性肾病患者24hu-TP,降低蛋白尿,减轻肾脏的损伤,延缓肾功能的减退,且保护肾功能,但慢性期优于急性期。
[Abstract]:Objective: to observe the clinical efficacy and safety of Danxi Tongfeng recipe in treating patients with gouty nephropathy (phlegm dampness stasis type), and to explore its mechanism. Methods: 60 patients with gouty nephropathy were divided into two groups: acute stage and chronic stage. To observe the changes of clinical symptoms, signs, serum uric acid and UAA, serum creatinine creatinine (SCR), 24 hour urinary protein (24 h urinary protein) before and after three courses of treatment, and to observe the changes of 24 hours urinary protein quantitative analysis before and after treatment, and to observe the changes of clinical symptoms, signs, serum creatinine creatinine, 24 hours urine protein, and so on, before and after treatment. The results were statistically analyzed and compared. Results the total effective rate of chronic phase group was 90, that of acute phase group was 80. The chronic stage group was superior to the acute phase group. There was significant difference between the two groups in the score of TCM syndrome before and after treatment, and the chronic phase group was better than the acute phase group .3.The difference between the two groups before and after treatment was significant (P 0.05), and the chronic phase group was superior to the acute phase group (.4. creatinine), and there was a significant difference between the two groups before and after treatment (P 0.05), and the chronic phase group was better than the acute phase group (.4. creatinine). Compared with before and after treatment, TG decreased significantly in urea nitrogen group, and there was significant difference between the two groups. There was no significant change in liver function between the two groups before and after treatment, but there was no statistical significance. Conclusion: 1. Danxi gout decoction can improve the liver function. The clinical symptoms and signs of patients with chronic gouty nephropathy were better than those of acute stage. 2. Danxi gout could significantly reduce UABUN and blood lipids in patients with chronic gouty nephropathy, which could effectively reduce 24hu-TPand proteinuria in patients with gouty nephropathy. The renal injury was alleviated, the decline of renal function was delayed, and the renal function was protected, but the chronic stage was superior to the acute stage.
【学位授予单位】：黑龙江省中医药科学院
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259;R277.5

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