隔药灸对高脂血症模型大鼠血脂水平、血液流变学及血清ALT、AST含量影响的研究

发布时间：2018-03-06 01:16

本文选题：隔药灸　切入点：高脂血症　出处：《广西中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:本实验拟通过观察隔药灸治疗高脂血症模型大鼠,观察其对高脂血症模型大鼠血脂水平、血液流变学及血清ALT、AST含量的影响,探讨隔药灸治疗高脂血症的作用机理,并评价其疗效,为临床上治疗高脂血症提供新的治疗思路和理论依据。方法:将80只雄性SD(Sprague-Dawleg)大鼠随机分为空白组、模型组、西药治疗组及隔药灸治疗组4组,每组各20只,对空白组以基础饲料喂养,其余各组采用喂养高脂饲料法建立高脂血症大鼠模型。造模成功后,西药治疗组予灌胃阿托伐他丁钙片治疗,隔药灸治疗组予隔药灸治疗,观察各组大鼠一般情况的变化,治疗结束后检测各组大鼠血脂水平、血液流变学及血清ALT、AST含量。结果:(1)与模型组相比,西药治疗组体重明显较轻,差异具有统计学意义(~▲P0.05);与西药治疗组相比,隔药灸治疗组体重明显较轻,差异有统计学意义(~□P0.05);(2)与空白组相比,模型组的TG、TC、LDL-C均明显升高,HDL-C明显降低,差异具有统计学意义(~▲P0.05);干预后,与模型组相比,西药治疗组和隔药灸治疗组的TG、TC、LDL-C均明显下降,HDL-C均明显增高,差异均具有统计学意义(~△P0.05,~□P0.05);隔药灸治疗组与西药治疗组的TG、TC、LDL-C、HDL-C相比,差异无统计学意义(P0.05);(3)与空白组相比,模型组的高切变率、低切变率、血浆黏度、红细胞压积、红细胞电泳时间、红细胞聚集指数均明显升高,差异具有统计学意义(~▲P0.05);干预后,与模型组相比,西药治疗组和隔药灸治疗组的高切变率、低切变率、血浆黏度、红细胞压积、红细胞电泳时间、红细胞聚集指数均明显下降,差异均具有统计学意义(~△P0.05,~□P0.05);隔药灸治疗组与西药治疗组的高切变率、低切变率、血浆黏度、红细胞压积、红细胞电泳时间、红细胞聚集指数相比,差异无统计学意义(P0.05);(4)与空白组相比,模型组的ALT、AST均明显升高,差异具有统计学意义(~▲P0.05);干预后,与模型组相比,西药治疗组和隔药灸治疗组的ALT、AST均明显下降,差异均具有统计学意义(~△P0.05,~□P0.05);隔药灸治疗组与西药治疗组的ALT、AST相比,差异均有统计学意义(~●P0.05)。结论:(1)隔药灸治疗不仅可有效的提高高脂血症模型大鼠的生存质量,而且可有效改善高脂血症模型大鼠的血脂水平和血液流变学,即隔药灸对高脂血症有较好的治疗效果;(2)隔药灸治疗可显著降低高脂血症模型大鼠血清的ALT、AST含量,说明隔药灸治疗对高脂血症模型大鼠的肝功能具有较好的保护效应;(3)隔药灸治疗高脂血症疗效显著,治疗方法绿色安全,值得临床推广应用。
[Abstract]:Objective: to observe the effect of drug separated moxibustion on hyperlipidemia model rats and its effects on blood lipid level, hemorheology and serum alt AST content in hyperlipidemia rats, and to explore the mechanism of drug separated moxibustion in treating hyperlipidemia. Methods: 80 male SDX Sprague-Dawley rats were randomly divided into blank group, model group, western medicine treatment group and medicine-separated moxibustion treatment group, with 20 rats in each group. The blank group was fed with basic diet and the other groups were fed with high fat diet to establish the hyperlipidemia rat model. After the model was established, the western medicine treatment group was treated with Atto vastatin calcium tablets, and the drug separated moxibustion group was treated with medicine-separated moxibustion. Observe the changes of the general situation of the rats in each group, detect the level of blood lipid, hemorheology and the content of alt AST in the rats of each group after treatment. Results: compared with the model group, the weight of the western medicine treatment group was significantly lower than that of the model group. Compared with the western medicine treatment group, the weight of moxibustion treated group was significantly lighter, and the difference was statistically significant (P 0.05) compared with the blank group, the LDL-C of the model group was significantly higher than that of the control group, and the HDL-C level of the model group was significantly lower than that of the western medicine treatment group. After intervention, compared with the model group, the LDL-C levels of TGV TCU in the western medicine treatment group and moxibustion separated group were significantly decreased and HDL-C was significantly increased, compared with the model group. There was no significant difference in HDL-C between moxibustion group and western medicine group (P 0.05). Compared with the blank group, the model group had high shear rate, low shear rate, plasma viscosity, hematocrit, hematocrit, and high shear rate, low shear rate, plasma viscosity, hematocrit, high shear rate, low shear rate, plasma viscosity, hematocrit, high shear rate, low shear rate, plasma viscosity, hematocrit, high shear rate, low shear rate, plasma viscosity, hematocrit, high shear rate, low shear rate, plasma viscosity and hematocrit. The erythrocyte electrophoresis time and erythrocyte aggregation index were significantly increased, and the difference was statistically significant (P 0.05), compared with the model group, the high shear rate, low shear rate and plasma viscosity of the western medicine treatment group and the drug separated moxibustion treatment group were higher than those of the model group. The hematocrit, the time of erythrocyte electrophoresis and the index of erythrocyte aggregation were all significantly decreased, and the differences were statistically significant. The high shear rate, low shear rate, plasma viscosity and hematocrit in the moxibustion treated group and the western medicine treatment group were higher than those in the western medicine treatment group. There was no significant difference in erythrocyte electrophoretic time and erythrocyte aggregation index (P 0.05) compared with the blank group, the alt of the model group was significantly higher than that of the control group, and the difference was statistically significant (P 0.05), and after intervention, it was compared with the model group. The alt of the western medicine treatment group and the medicine separated moxibustion treatment group were significantly decreased, and the difference was statistically significant (P 0.05) -P 0.05.The alt of the drug separated moxibustion treatment group was higher than that of the western medicine treatment group. Conclusion the drug separated moxibustion therapy can not only improve the quality of life of hyperlipidemia rats, but also improve the blood lipid level and hemorheology of hyperlipidemia rats. The drug separated moxibustion has a better therapeutic effect on hyperlipidemia. (2) the drug separated moxibustion treatment can significantly reduce the content of alt AST in serum of rats with hyperlipidemia. The results showed that moxibustion with separated medicine had a better protective effect on liver function of hyperlipidemia rats. (3) Medicine-separated moxibustion had significant curative effect on hyperlipidemia, and the treatment method was green and safe, so it was worth popularizing in clinic.
【学位授予单位】：广西中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R245

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