丹栀逍遥散治疗郁病（焦虑抑郁状态）肝郁气滞证的临床研究

发布时间：2018-03-06 05:28

本文选题：加味丹栀逍遥散　切入点：郁病　出处：《云南中医学院》2017年硕士论文　论文类型：学位论文

【摘要】：目的:观察加味丹栀逍遥散治疗郁病(焦虑抑郁状态)肝郁气滞证的临床疗效。方法:将64例受试者依照随机数字表分为治疗组、阳性对照组各32例。治疗组予加味丹栀逍遥散,服法:70ml/次,tid。阳性对照组口服黛力新,服用法:早餐中间服1片,用药时间为4周。治疗前和治疗2、4周记录中医证候、汉密尔顿焦虑(HAMA)、汉密尔顿抑郁(HAMD)量表,治疗前、治疗结束记录匹兹堡睡眠质量指数(PSQI)量表,以评定患者焦虑、抑郁程度及睡眠质量,统计各量表积分,总结有效率。.结果:1、加味丹栀逍遥散能明显减低受试者的中医症候量表积分、HAMA量表积分、HAMD量表积分、PSQI量表积分,治疗前后比较,有显著差异(P0.01)。中医症候量表总有效率为84.38%,HAMA量表总有效率为87.50%,HAMD量表总有效率为78.13%,PSQI量表总有效率为87.50%。2、黛力新能明显减低受试者的中医症候量表积分、HAMA量表积分、HAMD量表积分、PSQI量表积分,治疗前后比较,有显著差异(P0.01)。中医症候量表总有效率为78.13%,HAMA量表总有效率为81.28%,HAMD量表总有效率为84.38%,PSQI量表总有效率为84.38%。3、加味丹栀逍遥散与黛力新在减低患者中医症候量表积分、HAMA量表中精神焦虑积分、HAMD量表积分、PSQI量表积分方面比较,无统计学差异(P0.05),两者在减低HAMA量表躯体焦虑积分方面比较,有统计学意义(P0.05)。4、两组治疗期间血常规及肝肾功未出现异常,且未见不良反应发生。结论:加味丹栀逍遥散治疗郁病(焦虑抑郁状态)肝郁气滞证是有效且安全的,其在改善中医症状、精神焦虑症状、抑郁症状及失眠症状上与阳性对照药黛力新疗效相当,在改善躯体焦虑症状上优于黛力新,因而加味丹栀逍遥散值得临床推广运用及进一步实验研究。
[Abstract]:Objective: to observe the clinical effect of Jiawei Dan Zhi Xiaoyao Powder on stagnation of qi and liver qi in patients with depression (anxiety and depression). Methods: 64 subjects were divided into treatment group according to random digital table. There were 32 cases each in the positive control group. The treatment group was treated with Jiawei Dan Zhi Xiaoyao Powder, taking the method of: 70 ml / times tid. The positive control group took Delixin orally. The positive control group took 1 tablet in the middle of breakfast for 4 weeks. The TCM syndromes were recorded before treatment and 2 weeks after treatment. Before treatment, the Pittsburgh Sleep quality Index (PSQI) was recorded at the end of treatment to assess the anxiety, depression and sleep quality of the patients. Results the effective rate was 1.Results: 1, Jiawei Danzhi Xiaoyao Powder could significantly reduce the TCM symptom scale integral / Hamd scale integral and PSQI scale integral, and compare before and after treatment. The total effective rate of TCM symptom scale was 84.380.The total effective rate of Hama scale was 87.50 and the total effective rate of Hamd scale was 78.13and the total effective rate of PSQI scale was 87.50.2.The total effective rate of TCM symptom scale Hama scale and Hamd scale was obviously reduced. PSQI scale integral, Comparison before and after treatment, The total effective rate of TCM symptom scale was 81.28 and the total effective rate of Hamd scale was 84.38. The total effective rate of PSQI scale was 84.38.3. Jiawei Dan Zhi Xiaoyao San and Dai Lixin were in Hama scale. The scores of mental anxiety and Hamd scale were compared with those of PSQI scale. There was no significant difference between the two groups in reducing the score of body anxiety in HAMA scale. There was no significant difference between the two groups in terms of blood routine and liver and kidney function during treatment. Conclusion: Jiawei Danzhi Xiaoyao Powder is effective and safe in the treatment of stagnation of qi of liver in patients with depression of anxiety and depression. It can improve the symptoms of TCM and mental anxiety. The depressive symptoms and insomnia symptoms were similar to those of the positive control drug Delixin, which was superior to Delixin in improving the symptoms of somatic anxiety. Therefore, Jiawei Danzhi Xiaoyao Powder is worthy of clinical popularization and further experimental study.
【学位授予单位】：云南中医学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R277.7

【参考文献】