化痰活血扶正方治疗慢性乙型肝炎肝纤维化的临床研究

发布时间：2018-03-07 05:32

本文选题：慢性乙型肝炎　切入点：化痰扶正法　出处：《时珍国医国药》2017年07期 　论文类型：期刊论文

【摘要】：目的观察化痰活血扶正方对慢性乙型肝炎患者肝纤维化指标的影响及其临床疗效及作用机制。方法选择血清学及影像检查确诊为肝纤维化的慢性乙型肝炎60例,随机分为对照组30例,给予基础护肝治疗,配合拉米呋定100mg,一日一次;治疗组30例,在对照组的基础上加用化痰活血扶正方,每日一剂,日服两次,每次150ml,疗程3个月。观察治疗前及治疗一月及三月后的临床症状、体征、肝功能(AST、ALT、TBil、ALB、PT)、肝纤维化指标(HA、LN、PCⅢ、Ⅳ-C)、肝脾彩超检测指标及安全性监测。结果治疗组肝功能、肝纤维化指标、肝脾彩超检测指标均有显著改善,与治疗前相比有统计学意义(P0.05)。治疗组与对照组相比在肝纤维化指标、中医症状积分及肝脾彩超检测指标改善方面有显著差异(P0.05),在肝功能改善方面无显著差异((P0.05)。结论化痰活血扶正方可显着改善肝纤维化指标,减缓肝纤维化进展速度。
[Abstract]:Objective to observe the effect of Huatan Huoxue Fuzheng recipe (Huatan Huoxue Fuzheng recipe) on hepatic fibrosis in patients with chronic hepatitis B. methods 60 cases of chronic hepatitis B diagnosed by serology and imaging examination were selected. 30 patients in the control group were randomly divided into two groups: the control group (n = 30) was treated with basic liver protection therapy combined with lamivudine 100mg once in 1st, while the treatment group (n = 30) was treated with Huatan Huoxue Fuzheng recipe once a day, twice a day, on the basis of the control group. The clinical symptoms, signs, liver function, liver function, liver fibrosis index, liver fibrosis index, liver and spleen color Doppler ultrasonography were observed before treatment and after January and March. The indexes of liver fibrosis and liver and spleen color ultrasound were significantly improved compared with those before treatment (P 0.05). The indexes of liver fibrosis in the treatment group were higher than those in the control group. There was significant difference in the improvement of TCM symptom score and liver and spleen color Doppler examination index, but there was no significant difference in the improvement of liver function. Conclusion Huatan Huoxue Fuzheng decoction can significantly improve liver fibrosis index and slow down the progress of liver fibrosis.
【作者单位】：湖南中医药大学中西医结合学院;赣南医学院第一附属医院;赣南医学院;
【基金】：国家自然科学基金(No.81460707) 江西省赣州市指导性科技计划课题(No.2014066)
【分类号】：R259

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