不同强度穴位贴敷治疗中重度持续性变应性鼻炎:随机对照研究

发布时间：2018-03-07 06:10

本文选题：变应性鼻炎　切入点：持续性　出处：《中国针灸》2017年11期 　论文类型：期刊论文

【摘要】：目的:评价三伏天不同强度穴位贴敷对中重度持续性变应性鼻炎的临床疗效差异及安全性。方法:将160例中重度持续性变应性鼻炎患者随机分为治疗1组、治疗2组、治疗3组和安慰剂组,每组40例。4组取穴均为大椎、定喘、肺俞、脾俞、命门、膏肓、肾俞、气海。3个治疗组统一采用复方白芥子处方(白芥子、白芷、细辛、延胡索)共研细末。治疗1组以姜汁调和上述中药粉末(即姜调贴敷)制成药饼贴敷,治疗2组、治疗3组用蜂蜜调和中药粉末(即蜜调贴敷)制成药饼贴敷,安慰剂组用小米粉和蒸馏水制成外观相同的假药饼贴敷。其中治疗1组、治疗2组贴敷2 h,治疗3组、安慰剂组贴敷6 h,于三伏天期间每周贴敷1次,连续贴敷5周。观察4组患者治疗前、治疗5周后的鼻症状总分(TNSS)、鼻结膜炎生命质量调查问卷(RQLQ)评分、血液中嗜酸性粒细胞(EOS)计数,并比较4组的临床疗效,观察治疗各组皮肤不良反应发生率。结果:治疗后3个治疗组TNSS、RQLQ评分均较治疗前降低(P0.05,P0.01),其中治疗3组的改善程度优于治疗1组、治疗2组(均P0.05);治疗后3个治疗组EOS计数较治疗前均有所下降(均P0.05),各治疗组组间差异无统计学意义(均P0.05);治疗3组总有效率为85.0%(34/40),优于治疗1组的76.3%(29/38)、治疗2组的71.8%(28/39)及安慰剂组的5.0%(2/40,P0.05,P0.01);治疗2组、3组的皮肤不良反应发生率低于治疗1组(均P0.01)。结论:不同强度穴位贴敷均能改善中重度持续性变应性鼻炎患者的症状和生活质量。姜调贴敷刺激强度大,2 h贴敷后即可致皮肤出现水泡;蜜调贴敷较温和,未出现水泡,6 h蜜调贴敷疗效最佳。
[Abstract]:Objective: to evaluate the clinical efficacy and safety of acupoint application with different strengths in the treatment of moderate and severe persistent allergic rhinitis. Methods: 160 patients with moderate and severe persistent allergic rhinitis were randomly divided into treatment group 1 and treatment group 2. In treatment group 3 and placebo group, 40 cases in each group were taken points of Dazhui, Dingchuan, Feshu, Peshu, Shengmen, ointment, Shenshu and Qihai. The three treatment groups were treated with compound white mustard prescription (Radix angelicae dahuricae, Radix angelicae dahurica, Asarum). The treatment group 1 uses ginger juice to mix the above-mentioned traditional Chinese medicine powder (that is, ginger modified application) to make medicine cake patch, treatment group 2, treatment group 3 with honey and traditional Chinese medicine powder (that is, honey mixed application) to make medicine cake application, The placebo group was treated with rice flour and distilled water for the same appearance, and the treatment group 1, the treatment group 2, the treatment group 2 hours, the treatment group 3, the placebo group 6 hours, and the control group once a week during the period of three volts. The total score of nasal symptoms before and after 5 weeks of treatment, the score of RQLQQ, the count of eosinophils in blood and the clinical efficacy of the four groups were observed. Results: the TNSS RQLQ scores in the three treatment groups were lower than those before treatment, and the improvement degree of the treatment group was better than that of the treatment group 1. After treatment, the EOS count in the three treatment groups was lower than that before treatment (all P 0.05), and there was no significant difference among the treatment groups (all P 0.05); the total effective rate of the treatment group was 85.0% 40%, which was better than that of the treatment group 76 3 / 29% 3838, and that of the treatment group 2 was better than that of the control group (P 0 05). The total effective rate of the treatment group was 85. 0% 40%, which was better than that of the treatment group 1 (76. 3% / 38). 71.8% 28 / 39) and 5.0% 40% P0.05P0.01g in placebo group, and the incidence of adverse skin reaction in group 2 and group 3 was lower than that in group 1 (all P 0.01). Conclusion: acupoint application of different intensities can improve symptoms and quality of life of patients with moderate and severe persistent allergic rhinitis. Blisters appeared in the skin after two hours of application with high intensity of irritation. The effect of honey modulated application was better than that of non-blisters for 6 h.
【作者单位】：温州医科大学附属第二医院育英儿童医院;温州医科大学中美针灸康复研究所整合优化医学研究中心;
【基金】：浙江省中医药适宜技术培育项目:2014 ZP 005
【分类号】：R246.81

【相似文献】