补心软脉颗粒对气阴两虚夹有瘀热型冠心病心绞痛的临床疗效观察

发布时间：2018-03-07 13:39

本文选题：益气养阴　切入点：清热活血　出处：《南京中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：研究目的：观察补心软脉颗粒治疗气阴两虚夹有瘀热型冠心病心绞痛的临床疗效,并探讨可能的作用机制。研究方法：将符合诊断的冠心病心绞痛患者随机分为对照组20例,治疗组20例,对照组予常规西药治疗,治疗组在常规西药治疗的基础上加用补心软脉颗粒,连续服用8周,4周为1疗程,观察两个疗程。观察两组在治疗前后心绞痛及中医证候改善情况,心电图的变化,并检测血脂、血流变、hs-CRP、D-D二聚体、纤维蛋白原等相关指标,判断疗效。研究结果：①补心软脉组不仅可以明显缓解冠心病患者心绞痛症状,而且能改善中医证候,与对照组相比,有较好的疗效,P0.05,有统计学差异；②在调节血脂代谢紊乱方而,补心软脉组能明显减低血清中TC、TG、LDL,提高HDL水平,显著优于对照组；③在改善血液流变学方面,补心软脉组可降低全血粘度水平、血浆粘度、红细胞刚性指数、D-D二聚体、纤维蛋白原(FIB)含量,疗效优于对照组;④在抑制炎症反应方面,治疗后两组患者血清中hs-CRP水平均有所下降,但两组之间无统计学差异；⑤治疗期间未发现有不良反应。研究结论：补心软脉颗粒在治疗气阴两虚夹有瘀热证冠心病患者中有较好的临床疗效,可能与其调节脂质代谢、改善血液流变学有关。
[Abstract]:Objective: to observe the clinical effect of Buxinruangmai granule in treating angina pectoris of coronary heart disease with deficiency of Qi and yin, and to explore the possible mechanism. Methods: twenty patients with angina pectoris of coronary heart disease, who were diagnosed according to the diagnosis, were randomly divided into control group (n = 20). There were 20 cases in the treatment group, the control group was treated with routine western medicine, and the treatment group was treated with Buxinluangmai granule on the basis of the routine western medicine. The treatment group was treated continuously for 8 weeks and 4 weeks as a course of treatment. Observe two courses of treatment. Observe the improvement of angina pectoris and TCM syndromes before and after treatment, the changes of electrocardiogram, and detect blood lipid, hs-CRPPD-D dimer, fibrinogen and other related indexes. The results showed that the treatment group not only alleviated the symptoms of angina pectoris in patients with coronary heart disease, but also improved the syndrome of traditional Chinese medicine. Compared with the control group, it had a better curative effect (P 0.05). There was a statistical difference between the two groups in regulating the disorder of blood lipid metabolism. The level of HDL in serum was significantly decreased and the level of HDL was increased in the group of tonifying the heart soft vein, which was significantly better than that in the control group in improving hemorheology. The group of tonifying the soft vein of the heart could reduce the whole blood viscosity, plasma viscosity, erythrocyte rigidity index and D-D dimer. The content of fibrinogen FIB4 was better than that of the control group in inhibiting inflammatory reaction. After treatment, the serum levels of hs-CRP in both groups were lower than those in the control group. However, there was no statistical difference between the two groups during the treatment period, no adverse reactions were found. Conclusion: Buxinhuangmai granule has a better clinical effect in treating coronary heart disease with deficiency of Qi and Yin with blood stasis and heat, and may regulate lipid metabolism. Related to improving hemorheology.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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