冬肾丸治疗IgA肾病气阴两虚证的临床疗效观察

发布时间：2018-03-08 10:19

本文选题：冬肾丸　切入点：IgA肾病　出处：《湖南中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:本文主要是通过对冬肾丸治疗IgA肾病气阴两虚证患者的临床疗效观察,评估其用药价值及临床推广用药,改善患者临床症状,延缓其肾功能进展,提升患者生存质量。方法:将符合西医IgA肾病诊断标准和气阴两虚证中医辩证标准的40例患者随机分成治疗组20例、对照组20例,治疗组口服冬肾丸、观察组口服缬沙坦,总疗程为8周,其后观察其治疗前后的尿红细胞数、24小时尿蛋白定量、肾功能、中医证候等方面的变化及不良反应,评估其用药效果。结果:冬肾丸组和缬沙坦组两组治疗前均无统计学差异,具有齐同可比性。两组临床疗效和临床症状治疗前后对比,冬肾丸组总有效率为90(90)%,而缬沙坦组总有效率为70(75)%,从两组总有效率来看表明两者治疗均有效,然两组组间进行比较冬肾丸组明显优于缬沙坦组,差异有统计学意义(p0.05);两组在改善尿红细胞数、24小时尿蛋白方面冬肾丸组优于缬沙坦组(p0.05);两组中医证候总积分方面冬肾丸组和缬沙坦组较前均有下降,组间对比治疗组优于对照组,差异有统计学意义(p0.01)。结论:冬肾丸与缬沙坦均能改善患者症状、体征及生化指标,且两组间的比较显示冬肾丸组明显优于缬沙坦组,对于气阴两虚型的IgA肾病患者疗效突出,且无不良反应,值得进一步推广及临床用药。
[Abstract]:Objective: to evaluate the clinical efficacy of Dongshen pills in the treatment of IgA nephropathy with deficiency of qi and yin, to improve the clinical symptoms and delay the progress of renal function. Methods: 40 patients with IgA nephropathy and Qi-Yin deficiency syndrome were randomly divided into treatment group (n = 20) and control group (n = 20). The total course of treatment was 8 weeks. After the treatment, the changes and adverse reactions of urinary erythrocyte count in 24 hours urine protein quantity, renal function, TCM syndromes and other aspects were observed. Results: there was no statistical difference between the two groups before treatment and there was no comparison between the two groups. The clinical efficacy and symptoms of the two groups were compared before and after treatment. The total effective rate of Dongshen Pill group was 90%, while that of Valsartan group was 700.The total effective rate of the two groups showed that both groups were effective. However, compared between the two groups, the Dongshen pills group was obviously superior to the valsartan group, and the total effective rate of the two groups was higher than that of the valsartan group. There was significant difference between the two groups in improving urine erythrocyte count and 24 hours urine protein, the two groups were superior to valsartan group in improving the urine protein of 24 hours, the total integral of TCM syndromes of the two groups were lower than that of the previous group, the total score of TCM syndromes of the two groups was lower than that of the previous group, and there was no significant difference between the two groups in the total score of TCM syndromes. Conclusion: both Dongshen pills and valsartan can improve the symptoms, signs and biochemical indexes of the patients, and the comparison between the two groups shows that the Dongshen pills group is obviously superior to the valsartan group. For the patients with IgA nephropathy with deficiency of qi and yin, the curative effect is outstanding and no adverse reactions. It is worthy of further promotion and clinical use.
【学位授予单位】：湖南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.5

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