丹红化瘀口服液对视网膜中央静脉阻塞细胞因子网络的调节作用

发布时间：2018-03-09 16:33

本文选题：视网膜中央静脉阻塞　切入点：气滞血瘀血证　出处：《中国实验方剂学杂志》2017年18期 　论文类型：期刊论文

【摘要】：目的:观察丹红化瘀口服液治疗视网膜中央静脉阻塞气滞血瘀证的临床疗效及对房水和血清细胞因子的调节作用。方法:将144例患者就诊先后采用区组随机分为对照组和观察组。对照组采用雷珠单抗注射液,0.05 m L/次,1次/月,共3次。观察组口服丹红化瘀口服液,20 m L/次,3次/d。连续服用3个月。采用国际标准视力表检查最佳矫正视力(BCVA),进行气滞血瘀证评分,测量中心凹厚度(CMT),进行荧光素眼底血管造影记录视网膜血管渗漏面积、视网膜平均循环时间(RCT)和视网膜毛细血管无灌注区面积,均在治疗前后各评价1次。检测第1次和第3次手术前房水血管内皮生长因子(VEGF)和肿瘤坏死因子-α(TNF-α)水平,检测治疗前后血清VEGF,TNF-α,单核细胞趋化蛋白-1(MCP-1)和可溶性细胞间黏附分子-1(ICAM-1)。结果:观察组BCVA疗效总有效率为97.06%,高于对照组的85.07%(χ2=5.985,P0.05);观察组黄斑水肿疗效总有效率为94.12%,高于对照组的80.6%(χ2=5.605,P0.05);观察组血管渗漏面积和毛细血管无灌注区面积均小于对照组(P0.01),RCT时间缩短于对照组(P0.01);观察组BCVA高于对照组,CMT小于对照组,气滞血瘀证评分低于对照组(P0.01);第3次手术前观察组房水VEGF和TNF-α水平均低于对照组(P0.01);治疗后观察组血清VEGF,TNF-α,MCP-1和ICAM-1水平均低于对照组(P0.01)。结论:丹红化瘀口服液联合雷珠单抗注射能提高RVO患者的视力,并能调节房水VEGF,TNF-α和血清VEGF,TNF-α,MCP-1,ICAM-1等细胞因子。
[Abstract]:Objective: to observe the clinical efficacy of Danhong Huayu oral liquid in treating central retinal vein obstruction of qi stagnation and blood stasis syndrome and its regulating effect on aqueous humor and serum cytokines. Methods: 144 patients were randomly divided into four groups. Control group and observation group. A total of 3 times. The observation group took oral Danhong Huayu oral liquid 20 mL / time for 3 times / d for 3 months. The best corrected visual acuity (BCVAN) was checked by international standard visual acuity table, and the syndrome of Qi stagnation and blood stasis was scored. The thickness of fovea was measured and the area of retinal vascular leakage, mean retinal circulation time (RCTT) and no perfusion area of retinal capillaries were recorded by fluorescein fundus angiography (FFA). The levels of vascular endothelial growth factor (VEGF) and tumor necrosis factor- 伪 (TNF- 伪) in aqueous humor were measured before and after treatment. Before and after treatment, serum VEGF TNF- 伪, monocyte chemoattractant protein-1 (MCP-1) and soluble intercellular adhesion molecule-1 (ICAM-1) were detected. Results: the total effective rate of BCVA in the observation group was 97.06, which was higher than that in the control group (85.07%, 蠂 ~ 2 = 5.985, P 0.05), and the total effective rate of macular edema in the observation group was 94.12, which was higher than that in the control group. The BCVA of the observation group was higher than that of the control group, and that of the observation group was higher than that of the control group, and that of the observation group was higher than that of the control group, and that of the observation group was higher than that of the control group, and that of the observation group was lower than that of the control group. The scores of qi stagnation and blood stasis syndrome were lower than that of the control group (P 0.01), the levels of VEGF and TNF- 伪 in aqueous humor of the observation group were lower than those of the control group before the third operation, and the levels of MCP-1 and ICAM-1 in serum of the observation group were lower than those of the control group after treatment. Conclusion: Danhong Huayu oral liquid combined with Lei Zhu oral liquid is lower than that of the control group. Monoclonal antibody injection can improve the visual acuity of patients with RVO. The cytokines such as VEGFN TNF- 伪 and serum VEGF TNF- 伪 MCP-1 and ICAM-1 were also regulated in aqueous humor.
【作者单位】：儋州市第一人民医院;海南省中医院;
【基金】：海南省医学科技攻关项目(201602077)
【分类号】：R276.7

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