乌贝护膜汤治疗反流性食管炎的临床研究

发布时间：2018-03-11 06:25

本文选题：反流性食管炎　切入点：乌贝护膜汤　出处：《南京中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：随着工作压力的增大及不良生活方式的产生,反流性食管炎的发病率逐年升高,胃镜检查率也逐年升高。中医药治疗反流性食管炎有较好疗效,本课题从乌贝护膜汤治疗反流性食管炎的临床研究着手,从而观察乌贝护膜汤的临床疗效,分别通过理论和临床探讨思路,为进一步研究奠定基础。方法：随机选择2015年3月到2016年3月在名医堂门诊就诊的60例患者,且报告内容符合反流性食管炎诊断,治疗上予乌贝护膜汤煎剂口服治疗,早晚饭后30分钟口服,治疗疗程为8周。观察记录并分析比较治疗前后各症状评分,疗效评定,内镜下食管下段黏膜的愈合情况。结果：结合60例患者在主要症状,总体疗效及内镜下食管黏膜变化的前后比较,得出乌贝护膜汤能明显改善患者泛酸、烧心、嗳气、胸骨后不适等主要症状及咽喉不适、口干口苦、胃痛、纳差等次要症状,表2-45显示6例临床治愈,35例显效,14例有效,5例无效,总有效率为91.67%,食管黏膜在胃镜下显示32例愈合,3例显效,17例有效,8例无效,总有效率86.67%。胃镜疗效积分也比治疗前明显改善,且经成组配对t检验,治疗前后P0.01,证明乌贝护膜汤治疗反流性食管炎疗效优越。结论：乌贝护膜汤治疗反流性食管炎具有优势,在中医各证候、总疗效以及胃镜下食管黏膜愈合方面,都能明显改善,部分病例可以治愈,减少复发,降低副作用。
[Abstract]:Objective: with the increase of working pressure and bad lifestyle, the incidence of reflux esophagitis increased year by year, and the rate of gastroscopy increased year by year. This topic starts from the clinical research of Wubei Huiman decoction in the treatment of reflux esophagitis, so as to observe the clinical curative effect of Wubei Huimen decoction, and discuss the thoughts by theory and clinic, respectively. Methods: from March 2015 to March 2016, 60 patients were selected randomly, and the results were in accordance with the diagnosis of reflux esophagitis. The course of treatment was 8 weeks. The scores of symptoms, the evaluation of curative effect and the healing of lower esophageal mucosa under endoscope were observed, recorded and compared before and after treatment. Results: 60 patients were treated with the main symptoms. The general curative effect and the changes of esophageal mucosa under endoscope were compared. It was concluded that Ubai Huimen decoction could obviously improve the main symptoms such as pantothenic acid, heartburn, belching, post-sternal discomfort and other minor symptoms, such as pharynx and throat discomfort, dry mouth, stomachache, anorexia and other minor symptoms. Table 2-45 showed that 6 cases were cured in 35 cases, 14 cases were effective and 5 cases were ineffective, the total effective rate was 91.67. The esophageal mucosa showed 32 cases of healing under gastroscopy in 3 cases, and 17 cases were effective in 8 cases. The total effective rate was 86.67. The score of gastroscope curative effect was also obviously improved compared with that before treatment, and the total effective rate was 86.67%, the total effective rate was 86.67%, and the total effective rate was 86.67%. It was proved that Wubei Huimen decoction had superior curative effect on reflux esophagitis by paired t test before and after treatment. Conclusion: Wubei Huimen decoction has advantages in treating reflux esophagitis, and it has different syndromes in traditional Chinese medicine. The total curative effect and the healing of esophagus mucosa under gastroscope can be improved obviously, some cases can be cured, the recurrence can be reduced, and the side effects can be reduced.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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