基于中医传承辅助系统的儿童过敏性紫癜用药规律分析

发布时间：2018-03-12 10:32

本文选题：儿童　切入点：过敏性紫癜　出处：《山东中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:探讨儿童过敏性紫癜临床用药规律,为临床治疗提供思路。方法:选择山东中医药大学附属医院儿科病房2011年9月-2015年9月的儿童过敏性紫癜住院病例227例,录入中医传承辅助系统软件进行分析,得出结论。结果:(1)所纳入的227例病例中,男女比例为1.24:1,其中以5~9岁年龄段为主,病程多集中于1个月以内,皮肤型占74.4%,腹型占14.5%,关节型占6.2%,混合型占2.7%,肾型占2.2%。证型分布依次为:风热伤络、湿热痹阻、血热妄行、气不摄血、阴虚火旺。(2)常用前十位中药依次为甘草、苍术、紫草、防风、生地黄、荆芥、薏苡仁、牛蒡子、苦参、黄柏;清热药及解表药为主要用药类型;药物四气以寒性药物为主,五味以苦味药物为主,药物归肝经者居多;四妙散、消风散、甘露消毒丹、犀角地黄汤、补中益气汤为高频处方。(3)得到以甘草、苍术为代表的25个常用药物组合及其关联规则;得到关联度在0.03以上的以防风、蝉蜕为代表的药对共31对;得到以淡豆豉、金银花、芦根为代表的药物核心组合16对,进一步聚合成新处方共8首。结论:本病用药多以清热药、解表药、补虚药、利水渗湿药为主,方药功效主要为祛风清热、解毒活血、清热祛湿、健脾益气,提示风、湿、热、瘀为主要致病因素,临床治法、方药、药物组合、新方聚合等均是围绕此四类制定和配伍的。
[Abstract]:Objective: to explore the rule of clinical drug use in children with Henoch-Schonlein purpura and to provide some ideas for clinical treatment. Methods: a total of 227 cases of children with Henoch-Schonlein purpura from September 2011 to September 2015 in pediatric ward of affiliated Hospital of Shandong University of Chinese Medicine were selected. The results showed that the ratio of male to female was 1.24: 1 out of the 227 cases included in the study. Among them, the age group was 5 to 9 years old, and the course of disease was mostly within one month. The skin type accounted for 74.4%, abdominal type 14.5%, joint type 6.2%, mixed type 2.7%, kidney type 2.2. The distribution of syndrome type was as follows: wind and heat injury, dampness and heat obstruction, blood heat disorder, qi not absorbing blood, yin deficiency and fire flourishing, etc.) the top ten Chinese medicines were Glycyrrhiza, Atractylodes and Rhizoma Rhizome. Fangfeng, Rehmannia, Schizonepeta, Coix seed, Fructus Arctii, Sophora flavescens, Cortex Phellodendri; Heat-clearing drugs and antiepidermic drugs are the main drug types; the four drugs are mainly cold drugs, the five flavors are mainly bitter drugs, and the drugs belong to the liver Meridian, most of them belong to the liver Classic; Simiao San, Xiaofeng San, Gannuxiao Dan, Rhinoceros Corner Rehmannia decoction, Buzhong Yiqi decoction as high frequency prescription. 3) 25 common drug combinations and association rules represented by Licorice and Atractylodes were obtained, and Fangfeng with correlation degree above 0.03 was obtained. A total of 31 pairs of drug pairs represented by cicada slough were obtained. 16 pairs of drug core combinations, represented by black bean, honeysuckle and root, were obtained, and further aggregated into 8 new prescriptions. The efficacy of the prescription is mainly to dispel wind and clear heat, detoxify and activate blood, clear heat and remove dampness, invigorate spleen and invigorate qi, suggest that wind, dampness, heat and blood stasis are the main pathogenic factors, clinical treatment method, prescription medicine, drug combination, Xinfang polymerization and so on are around these four categories of formulation and compatibility.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R272

【相似文献】