心律康宁丸治疗病态窦房结综合征（心肾阳虚）临床观察

发布时间：2018-03-12 23:21

本文选题：病窦综合征　切入点：心肾阳虚　出处：《河南中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:本课题通过观察心律康宁丸治疗病态窦房结综合征(心肾阳虚)的临床有效性和安全性,进而为中医药治疗病窦综合征提供新方法、新思路,为中药新药的开发提供临床依据。方法:筛选出临床确诊为病窦综合征(心肾阳虚)的患者60例,随机分为对照组和治疗组各30例,为确保受试者安全,对于具有冠心病、高血压病等基础病的患者,在常规用药的基础上,对照组给以硫酸沙丁胺醇片(2mg)一次2片,日3次治疗。治疗组应用心律康宁丸,每次6g,日3次治疗。连续治疗8周。观察对比治疗前后患者的血、尿、粪常规、肝肾功能等安全性指标和常规心电图、24小时动态心电图和中医临床证候等疗效性指标的变化,并应用SPSS19.0统计软件进行数据统计分析。结果:1、中医证候积分方面两组均有改善,治疗组优于对照组(P0.05)。2、24小时动态心电图测得的总心率、平均心率、最慢心率和静息心率,两组均有提高,治疗组优于对照组(P0.05)。3、在治疗过程中,两组患者一般状况均可,均未发生不良反应事件,肝、肾功能在治疗前后相比差异无统计学意义(P0.05)。结论:1、心律康宁丸治疗病窦(心肾阳虚)的患者疗效确切,可明显改善患者的心悸、胸闷等临床症状。2、心律康宁丸可明显提高病窦患者24小时心率总数及平均心率和最慢心律。3、心律康宁丸治疗病窦(心肾阳虚)未发现不良反应,具有良好的安全性。
[Abstract]:Objective: to observe the clinical efficacy and safety of arrhythmia kangning pills in treating sick sinus syndrome (SSS), and to provide a new method and new idea for the treatment of sick sinus syndrome with TCM. Methods: 60 patients with sinusoidal syndrome (deficiency of heart and kidney yang) were selected and randomly divided into control group (30 cases) and treatment group (30 cases). Patients with basic diseases such as hypertension were treated with 2 tablets of salbutamol sulfate and 3 times a day in the control group on the basis of routine medication. The changes of blood, urine, fecal routine, liver and kidney function, 24 hour ambulatory electrocardiogram (ECG) and clinical symptoms of TCM were observed and compared before and after treatment. The SPSS19.0 software was used to analyze the data. Results the score of TCM syndromes was improved in both groups. The total heart rate, mean heart rate, slowest heart rate and resting heart rate in the treatment group were better than those in the control group. The treatment group was superior to the control group (P 0.05). In the course of treatment, the general condition of the two groups were all, no adverse events occurred, liver, liver, liver, liver, liver, liver, liver, liver, liver, liver, liver, liver, liver, liver, liver, liver, There was no significant difference in renal function between before and after treatment (P 0.05). Conclusion: the treatment of heart and kidney yang deficiency in patients with heart and kidney yang deficiency can obviously improve the palpitation of patients with heart palpitations. The clinical symptoms such as chest tightness and other clinical symptoms, such as chest tightness, and so on, could be significantly increased by RKN. The total heart rate, mean heart rate and slowest heart rate were significantly increased in patients with diseased sinuses. No adverse reactions were found in the treatment of sick sinuses (deficiency of heart and kidney yang) with good safety.
【学位授予单位】：河南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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