痰瘀同治法治疗冠心病心绞痛痰瘀证临床疗效的系统评价

发布时间：2018-03-13 00:28

本文选题：冠心病心绞痛　切入点：痰瘀证　出处：《山东中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:系统评价痰瘀同治法治疗冠心病心绞痛痰瘀证的临床疗效,总结归纳治疗本病的用药和组方规律。方法:运用RevMan5.3软件进行Meta-分析、倒漏斗图分析以及敏感性分析;搜集治疗冠心病心绞痛痰瘀证的中药方剂,借助中医传承辅助平台系统进行方药分析。结果:1.Meta-分析结果示:痰瘀同治法干预的治疗组在治疗后心绞痛有效率、心电图有效率、中医证候的有效率和高密度脂蛋白水平方面均高于对照组(P0.05),甘油三酯、总胆固醇、低密度脂蛋白、全血黏度低切值、全血黏度高切值、血浆黏度、纤维蛋白原、红细胞压积水平均低于对照组(P0.05);2.倒漏斗图分析示:心电图、中医证候的有效率及总胆固醇、甘油三酯、高密度脂蛋白和低密度脂蛋白指标可能存在发表偏倚;3.敏感性分析示:两种不同的统计分析方法所得的结论未见不一致者;4.方药分析结果示:治疗冠心病心绞痛痰瘀证的药物中使用最多的为半夏、丹参,提取药物核心组合后得到5个新方组合。结论:1.痰瘀同治法治疗冠心病心绞痛痰瘀证具有较好的临床疗效和安全性;2.冠心病心绞痛痰瘀证的治疗有痰、瘀偏重之分,治疗原则以通为主;3.为痰瘀同治法治疗冠心病心绞痛痰瘀证提供了科学依据,为临床遣方用药提供了新思路。
[Abstract]:Objective: to evaluate the clinical effect of phlegm and blood stasis therapy in treating angina pectoris and phlegm stasis syndrome of coronary heart disease (CHD), and summarize the medication and prescription rule. Methods: Meta- analysis, inverted funnel graph analysis and sensitivity analysis were carried out with RevMan5.3 software. Collect the prescription of traditional Chinese medicine for treating angina pectoris of coronary heart disease, and analyze the prescription with the aid of traditional Chinese medicine system. Results 1. The result of Meta- analysis shows that the effective rate of angina pectoris and electrocardiogram in the treatment group treated with phlegm and blood stasis treatment method are effective after treatment. The effective rate and high density lipoprotein level of TCM syndrome were higher than that of control group (P 0.05), triglyceride, total cholesterol, low density lipoprotein, low shear value of whole blood viscosity, high shear value of whole blood viscosity, plasma viscosity, fibrinogen, The level of hematocrit was lower than that of control group (P 0.05) 2.The analysis of inverted funnel graph showed that electrocardiogram, effective rate of TCM syndromes, total cholesterol, triglyceride, High density lipoprotein and low density lipoprotein may have publication bias 3.Sensitivity analysis shows: the conclusions of two different statistical analysis methods are not consistent. 4. Prescription analysis shows: treatment of angina pectoris of coronary heart disease. Among the drugs with phlegm-stasis syndrome, Pinellia ternata was the most used. Salvia miltiorrhiza, after extracting the core combination of medicine, five new prescription combinations were obtained. Conclusion: 1. Phlegm and blood stasis combined therapy has good clinical efficacy and safety in treating angina pectoris and phlegm stasis syndrome of coronary heart disease 2.There are phlegm and blood stasis in the treatment of coronary heart disease angina pectoris and phlegm stasis syndrome. 3. It provides a scientific basis for the treatment of angina pectoris and phlegm stasis syndrome of coronary heart disease, and provides a new idea for clinical prescriptions.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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