温针灸预处理对冷冻胚胎移植者子宫内膜容受性的影响

发布时间：2018-03-13 03:31

本文选题：冷冻胚胎移植　切入点：温针灸　出处：《中国针灸》2017年08期 　论文类型：期刊论文

【摘要】：目的:探讨温针灸预处理对冷冻胚胎移植(frozen-thawed embryo transfer,FET)者子宫内膜容受性的影响。方法:选取反复胚胎移植(ET)失败、B超提示卵泡期子宫内膜为C型、经宫腔镜检查诊断为子宫内膜炎、准备行FET的患者56例,随机分为观察组(25例)和对照组(31例)。观察组在胚胎移植前3个月,于月经期用抗生素,月经干净后开始进行温针灸治疗,穴取中脘、天枢、关元、中极、子宫、梁丘、足三里、上巨虚、下巨虚,每日1次,直到排卵前停止,排卵后开始口服地屈孕酮;对照组在胚胎移植前3个月,于月经期用抗生素,排卵后开始口服地屈孕酮,两组均按各自方案连续进行3个月经周期。观察两组患者子宫内膜厚度、子宫内膜类型和子宫内膜下血流的变化及FET临床结局。结果:两组子宫内膜形态及内膜下血流均较治疗前改善(均P0.01),且观察组较对照组更明显(均P0.01);观察组胚胎种植率及临床妊娠率明显高于对照组(均P0.01),早期流产率较低(P0.01)。结论:温针灸可能通过改善子宫内膜形态及内膜下血流,从而改善FET患者子宫内膜容受性,可提高胚胎种植率及临床妊娠率,降低早期流产率。
[Abstract]:Objective: to investigate the effect of warm acupuncture and moxibustion preconditioning on endometrial receptivity in frozen embryo transfer embryo transfer. Methods: repeated embryo transfer failed, B-mode ultrasound showed that the follicular endometrium was type C, and was diagnosed as endometritis by hysteroscopy. 56 patients with FET were randomly divided into two groups: the observation group (n = 25) and the control group (n = 31). Midpole, uterus, Liang Qiu, Zusanli, Upper Juxu, Lower Juxu, once a day, until the ovulation stops, after ovulation begins to take Diproprogesterone orally; the control group is treated with antibiotics during menstrual period 3 months before embryo transfer. After ovulation, oral administration of Diproprogesterone was performed in both groups. The endometrial thickness of the two groups was observed by three consecutive menstrual cycles in accordance with their respective protocols. The changes of endometrial type and subendometrial blood flow and the clinical outcome of FET. Results: the changes of endometrial morphology and subendometrial blood flow in both groups were improved compared with those before treatment (P0.01), and the observation group was more obvious than the control group (all P0.01); the embryo in the observation group was better than that in the control group (P0.01). The implantation rate and clinical pregnancy rate were significantly higher than those in the control group (all P 0.01), and the early abortion rate was lower than that in the control group. Conclusion: warm acupuncture may improve the endometrial morphology and subendometrial blood flow. Thus improving the endometrial receptivity of FET patients can increase the embryo implantation rate and clinical pregnancy rate and reduce the rate of early abortion.
【作者单位】：佛山市妇幼保健院生殖中心;佛山市妇幼保健院中医科;
【分类号】：R246.3

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