徐氏泄肝和胃方结合糊剂卧位服药法治疗反流性食管炎的疗效评价及对生活质量的影响

发布时间：2018-03-13 14:43

本文选题：反流性食管炎　切入点：徐景藩　出处：《南京中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：观察徐氏泄肝和胃方结合糊剂卧位服药法治疗反流性食管炎的临床疗效及对生活质量的影响,探讨徐景藩诊治反流性食管炎的经验。方法：根据纳入标准,收集就诊于江苏省中医院普内科、脾胃病科、消化内镜中心门诊符合反流性食管炎肝胃郁热证诊断标准的患者共57例。随机分为两组,治疗组28例,对照组29例,治疗组予口服徐氏泄肝和胃方浓煎(每日1剂,早晚分服),并结合糊剂卧位服药法,共治疗8周；对照组予奥美拉唑胶囊(每次20mg,每日两次,餐前半小时服用)加铝镁加混悬液(每次15ml,每日3次)共治疗8周。观察两组治疗前后症状积分及生活质量积分的变化,进行相关统计学分析。结果：1.本研究治疗组有效率78.57%,对照组有效率82.76%,两组有效率经统计学处理无明显差异性(P0.05)。2.治疗组在治疗后的临床症状改善方面与治疗前比较有显著差异(P0.01)；对照组在治疗后的临床症状改善方面与治疗前比较有差异(P0.05)；除胃脘痛症状外,治疗后两组中医症状积分有差异(P0.05),治疗组中医症状积分的改善程度优于对照组。3.治疗组与对照组治疗前后在改善患者生活质量积分相比较均具有差异性(P0.05),两组在治疗结束后的生活质量积分方面有显著差异(P0.01)。4.在治疗结束3个月后与治疗8周时相比较,治疗组两次积分无显著差异,对照组两次积分有差异(P0.01),两组在治疗3个月后积分有统计学差异(P0.01)。结论：徐氏泄肝和胃方结合糊剂卧位服药法能显著改善反流性食管炎的临床症状,降低反流性食管炎复发率。值得进一步推广应用,造福患者。
[Abstract]:Objective: to observe the clinical curative effect and influence on quality of life of Xuxiegan and Weifang combined with supine medicine in the treatment of reflux esophagitis. Methods: according to the inclusive criteria, Xu Jingfan's experience in the treatment of reflux esophagitis was discussed. A total of 57 patients who met the diagnostic criteria of liver and stomach stagnation in reflux esophagitis were collected and randomly divided into two groups: treatment group (n = 28) and control group (n = 29). The treatment group was treated for 8 weeks by oral decoction of Xuxiegan and Wei decoction (1 dose per day, morning and evening, and combined with the method of taking medicine in supine position of paste), while the control group was treated with omeprazole capsule (20 mg per day, twice a day), the control group was treated with omeprazole capsule (20 mg per day, twice a day). The patients were treated with aluminum, magnesium and suspension (15 ml / day, 3 times a day) for 8 weeks. The changes of symptom score and quality of life score before and after treatment were observed in both groups. The effective rate of the treatment group was 78.57 and that of the control group was 82.76. There was no significant difference between the two groups in the effective rate after treatment (P 0.05). 2. The improvement of clinical symptoms in the treatment group was compared with that before treatment. There was a significant difference between the two groups in the improvement of clinical symptoms after treatment (P 0.05), in addition to the symptoms of epigastric pain, there was significant difference between the control group and the control group in the improvement of clinical symptoms after treatment. The improvement degree of TCM symptom integral in the treatment group was better than that in the control group. 3. There was significant difference between the treatment group and the control group in improving the quality of life score of the patients before and after treatment. There was significant difference in quality of life score after treatment (P 0.01). 4. 3 months after treatment and 8 weeks after treatment, there was a significant difference in quality of life score. There was no significant difference between the treatment group and the treatment group. In the control group, there was significant difference in the scores between the two groups after 3 months of treatment (P 0.01). Conclusion: the combination of Xu's Xiaogan and Wei Fang with supine medicine can significantly improve the clinical symptoms of reflux esophagitis. To reduce the recurrence rate of reflux esophagitis.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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