妇爽散治疗外阴阴道假丝酵母菌病的临床观察

发布时间：2018-03-16 12:34

本文选题：VVC　切入点：妇爽散　出处：《云南中医学院》2017年硕士论文　论文类型：学位论文

【摘要】：目的:观察“妇爽散”及“妇爽散”联合双唑泰泡腾片局部给药治疗外阴阴道假丝酵母菌病(vulvovaginal candidiasis,VVC)的临床疗效,为探寻治疗VVC最佳用药方案提供临床研究资料。方法:将选择符合纳入标准的90例患者随机分为三组,即两组观察组与一组对照组,每组各30例:中药组予中药妇爽散阴部坐浴及阴道冲洗治疗;中西药组予妇爽散阴部坐浴+双唑泰泡腾片阴道治疗;对照组即西药组,予双唑泰泡腾片阴道治疗。各组均以七天为一个疗程。通过观察三组患者治疗前后临床症状(阴部瘙痒或灼热疼痛、带下等)、局部体征、白带常规与五联酶学检测等方面的变化进行总结归纳,利用SPSS21.0统计软件,对临床收集的数据通过秩和检验、c2检验及t检验等方法,进行统计分析。结果:1、中药组、中西药组与西药组在假丝酵母菌清除率上分别为93.3%、100%、100%,临床症状总疗效分别为80%、96.7%、86.7%,三组治疗在假丝酵母菌清除及临床症状总疗效差异无统计学意义(P0.05)。2、白带常规与五联酶学检测各项指标观察示:(1)清洁度方面,三组疗效均非常显著(P0.01),组间比较差异无统计学意义(P0.05);(2)在白细胞酯酶、脯氨酸氨基肽酶方面,中西药组疗效显著(P0.05);(3)在过氧化氢方面,中西药组疗效显著(P0.05);(4)在乙酰氨基葡萄糖苷酶方面,中西药组疗效非常显著(P0.01)。3、患者自觉阴部瘙痒、带下量、带下异味的改善方面,三组均疗效非常显著(P0.01)。在自觉带下量改善方面,中药组优于中西药组(P0.05),中西药组优于西药组(P0.05);在自觉带下色质改善方面,中药组显著优于另两组(P0.01)、中西药组显著优于西药组(P0.01);4、在改善妇检局部体征上,中药组疗效显著,差异有统计学意义(P0.05)。其中阴道分泌物改善方面,中药组效果非常显著,差异有显著统计学意义(P0.01)。结论:1、妇爽散治疗VVC临床疗效效果肯定,并能有效改善伴随的症状,提高患者生活质量,疗效与双唑泰泡腾片相近。2、妇爽散在改善VVC患者自觉带下色质、妇检局部体征、阴道分泌物量多方面优于双唑泰泡腾片。3、妇爽散联合双唑泰泡腾片用药在改善VVC患者自觉带下量、色质改善方面疗效优于单纯用双唑泰泡腾片。并能明显改善白带的五联酶学指标。
[Abstract]:Objective: to observe the clinical effect of "Fushuang Powder" and "Fushuang Powder" combined with bizolidate effervescent tablet in the treatment of vulvovaginal candidiasis (VVC). Methods: 90 patients who met the inclusion criteria were randomly divided into three groups: two observation groups and one control group. There were 30 cases in each group: the Chinese medicine group was treated with traditional Chinese medicine Fushuangsan pudendal sitting bath and vaginal washing; the Chinese and western medicine group received the vaginal treatment of Fushuangsan pudendal biszolidate effervescent tablet; the control group was the western medicine group. The patients in each group were treated with seven days as a course of treatment. The clinical symptoms of the three groups were observed before and after treatment (pruritus or burning pain in the pudendal region, with lower and equal symptoms, local signs, etc.). The changes of leucorrhea routine and pentagonal enzymology were summarized and summarized. The clinical data collected were statistically analyzed by rank sum test and t test by using SPSS21.0 software. The clearance rates of Candida cerevisiae in the Chinese and western medicine groups were 93.3100 and 100, respectively, and the total clinical symptoms were 86.70.There was no significant difference between the three groups in the clearance of Candida cerevisiae and the total curative effect of clinical symptoms, while the leucorrhea routine and the pentaclase were not significantly different from those in the three groups. There was no significant difference between the three groups in the clearance of Candida cerevisiae and the total curative effect of clinical symptoms. In terms of cleanliness, There was no significant difference between the three groups in the leucocyte esterase and proline aminopeptidase, while in the Chinese and western medicine group the curative effect was significantly higher than that of the western medicine group in hydrogen peroxide. The curative effect of the traditional Chinese and Western medicine group was significant (P0.05Glucosidase) in the acetylglucosaminidase group, the curative effect of the traditional Chinese and western medicine group was very significant (P 0.01). The patients were aware of the pruritus of the pudenda, the quantity and the smell of the vulva. The effect of the three groups was very significant in the improvement of the quantity under the conscious belt. The Chinese medicine group was superior to the Chinese and western medicine group (P 0.05), the traditional Chinese medicine group was superior to the western medicine group (P 0.05), the traditional Chinese medicine group was significantly better than the other two groups in improving the color quality under the conscious belt, and the traditional Chinese medicine group was significantly better than the western medicine group (P 0.01). The difference was statistically significant (P 0.05). In the improvement of vaginal secretion, the effect of traditional Chinese medicine group was very significant, and the difference was statistically significant. Conclusion the clinical effect of Wushuangsan in treating VVC is positive, and it can effectively improve the accompanying symptoms. To improve the quality of life of patients, the curative effect was similar to that of bizolidate effervescent tablets. The effect of Fushuangsan was to improve the color quality and local signs of VVC patients. The amount of vaginal secretions was better than that of bizolidate effervescent tablets in many aspects. The dosage of Fushuang Powder combined with Bizolidate effervescent tablets was improved in patients with VVC. The effect of color improvement was better than that of biszolidine effervescent tablet alone, and it could obviously improve the pentagonal enzyme index of leucorrhea.
【学位授予单位】：云南中医学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R271.9

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