外用复方黄连膏治疗慢性顽固性湿疹随机对照临床研究

发布时间：2018-03-16 22:37

本文选题：复方黄连膏　切入点：慢性湿疹　出处：《北京中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：研究目的复方黄连膏是北京中医院的传统中药制剂,本研究意在探索复方黄连膏治疗湿疹的临床疗效及其作用机理,观察其临床使用的安全性,从中医药外治学角度观察复方黄连膏对湿疹的治疗作用,为基于"清热利湿解毒法"创立的复方黄连膏在治疗慢性湿疹的应用提供科学依据。研究方法采用随机、平行、双侧对称皮疹自身配对、安慰剂对照研究。探讨外用复方黄连膏治疗"湿毒郁肤"证慢性湿疹的临床疗效和安全性。主要评价指标包括慢性湿疹的皮肤面积、皮疹颜色、皮疹形态等临床体征和瘙痒程度、心烦等中医临床症候及皮肤屏障测定及安全性指标进行客观定量评分。研究结果观察复方黄连膏改善"湿毒郁肤"证湿疹疗效,治疗组总有效率90.77%,优于对照组的总有效率56.92%,且差异有统计学意义(p0.05)。对比治疗前后皮损瘙痒评分、面积大小及皮疹形态均有显著改善,且皮肤屏障功能,治疗组水分、油脂较对照组疗效显著。结合两组之间有效率的比较,说明复方黄连膏外治"湿毒郁肤"证慢性湿疹的具有确切的临床疗效,且65例患者中无用药后发生不良反应者,明确了复方黄连膏的安全性。研究结论复方黄连膏治疗"湿毒郁肤"证湿疹具有较好疗效。
[Abstract]:Objective to explore the clinical efficacy and mechanism of compound Coptis plaster in treating eczema and to observe the safety of its clinical use. To observe the therapeutic effect of compound Coptis ointment on eczema from the perspective of external treatment of traditional Chinese medicine, to provide a scientific basis for the application of compound Coptis ointment based on "clearing heat, promoting dampness and detoxification" in the treatment of chronic eczema. A self-matched, placebo-controlled study of bilateral symmetrical skin rash. To explore the clinical efficacy and safety of compound Huanglian ointment in the treatment of chronic eczema with "dampness toxin depression skin" syndrome. The main evaluation indexes include the skin area and skin color of chronic eczema. The clinical signs and pruritus degree such as the appearance of rash and the degree of pruritus, the clinical symptoms of traditional Chinese medicine such as irritation, the determination of skin barrier and the safety index were evaluated objectively and quantitatively. The results of the study were to observe the effect of compound Huanglian ointment on improving the eczema of "dampness toxin depression skin" syndrome. The total effective rate of the treatment group was 90.77, which was better than that of the control group (56.92%), and the difference was statistically significant (p 0.05). The curative effect of oil and fat was more obvious than that of control group. Combined with the comparison of effective rate between the two groups, it showed that compound Huanglian ointment had definite clinical effect in treating chronic eczema with "dampness toxin depression skin" syndrome, and there were no adverse reactions in 65 patients. Conclusion compound Coptis ointment is effective in treating eczema of "dampness toxin depression skin".
【学位授予单位】：北京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R275.9

【参考文献】