类风湿关节炎病证结合动物模型研究进展

发布时间：2018-03-17 05:07

本文选题：类风湿关节炎　切入点：病证结合　出处：《中国中医基础医学杂志》2017年10期 　论文类型：期刊论文

【摘要】：类风湿关节炎(rheumatoid arthritis,RA)是一种慢性自身免疫功能障碍疾病,其病因及发病机制尚不明确。长期临床研究表明,中医药治疗类风湿关节炎具有独特优势,加大对中医药的研究必须借助动物模型,由此构建具有中医证候特征的动物模型是关键。病证结合动物模型结合现代医学"病"和中医"证"的优势,是目前应用最广泛的中医动物模型。笔者拟对近年来RA病证结合动物模型进行综述,并对其存在的问题进行思考,以期推动RA病证结合动物模型及其证候生物学机制的研究进展。
[Abstract]:Rheumatoid arthritis (RA) is a chronic autoimmune disorder. The etiology and pathogenesis of rheumatoid arthritis (RA) are not clear. Long-term clinical studies have shown that Chinese medicine has a unique advantage in treating rheumatoid arthritis. In order to increase the research on traditional Chinese medicine, we must rely on animal models, so it is the key to construct animal models with the characteristics of TCM syndromes. The combination of disease and syndrome combined with modern medical "disease" and TCM "syndrome" is the advantage. It is the most widely used animal model of traditional Chinese medicine at present. The author intends to summarize the animal model of RA disease combined with syndromes in recent years, and think about its existing problems. In order to promote RA combined animal model and syndromes biological mechanism research progress.
【作者单位】：湖南中医药大学;
【基金】：国家自然科学基金资助项目(81373540)-基于PI3KAkt-m TOR信号传导通路探讨青风藤配伍白芍治疗类风湿关节炎“相使”为用的机理湖南省高层次卫生人才“225”工程医学学科骨干人才培养对象项目湖南中医药大学中医诊断国家重点学科开放基金项目(2014-08)-基于悬液芯片技术的RA寒湿痹阻证生物标志物及证候诊断模型研究;基于代谢组学的类风湿关节炎风寒湿痹证病证结合模型证候生物学基础研究(2015ZYZD05);类风湿关节炎活动期中医证素及其与病理改变的关系研究(2015ZYZD15);湖南中医药大学“科技创新团队”资助项目(201503)-风湿免疫疾病中医药诊治转化医学研究
【分类号】：R259;R-332

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