消胀抑瘤方联合化疗治疗胃癌所致恶性腹腔积液35例临床观察

发布时间：2018-03-18 03:11

本文选题：胃癌　切入点：恶性腹腔积液　出处：《中医杂志》2017年11期 　论文类型：期刊论文

【摘要】：目的探讨消胀抑瘤方联合全身及腹腔内化疗治疗晚期胃癌所致恶性腹腔积液的临床疗效及安全性。方法 70例晚期胃癌所致恶性腹腔积液辨证属肝郁脾虚证型患者,按随机数表法分成治疗组和对照组各35例。对照组仅给予左亚叶酸钙100 mg/m~2+5-氟尿嘧啶2.0 g/m~2+紫杉醇95 mg/m2(静脉滴注)+紫杉醇30 mg/m~2(腹腔灌注化疗)双周方案化疗。治疗组采用相同方案化疗,并口服消胀抑瘤方,每日1剂。两组疗程均为30天,疗程结束后观察两组患者腹腔积液疗效及中医证候疗效,治疗期间记录引流腹腔积液次数、化疗毒副反应发生情况。结果治疗组腹腔积液疗效有效率为62.86%,稳定率为85.71%;对照组分别为为51.43%和62.86%,治疗组稳定率优于对照组(P0.05)。治疗组引流腹水次数显著少于对照组(P0.05)。治疗组恶心、呕吐,腹泻,中性粒细胞下降,转氨酶升高等化疗毒副反应的发生率显著低于对照组(P0.05)。治疗组中医证候疗效优于对照组(P0.05)。结论消胀抑瘤方联合全身及腹腔内化疗治疗肝郁脾虚型胃癌所致恶性腹腔积液患者,与单纯化疗相比,可提高腹腔积液治疗稳定率,减少治疗过程中引流腹水次数,减轻化疗毒副反应,改善中医证候,且临床应用安全。
[Abstract]:Objective to investigate the clinical efficacy and safety of Xiaodong Yi tumor recipe combined with systemic and intraperitoneal chemotherapy in the treatment of malignant peritoneal effusion caused by advanced gastric cancer. Methods 70 patients with malignant peritoneal effusion caused by advanced gastric cancer were diagnosed as liver stagnation and spleen deficiency syndrome. According to the random list method, the treatment group and the control group were divided into treatment group (n = 35) and control group (n = 35). The control group was treated with only levoflavone 100 mg/m~2 5-fluorouracil 2.0 g / m ~ 2 paclitaxel 95 mg / m ~ (2) paclitaxel 30 mg / m ~ (2) paclitaxel 30 mg 路m ~ (2) (intraperitoneal infusion chemotherapy) biweekly chemotherapy. The group received the same regimen of chemotherapy, The treatment course of both groups was 30 days. After the treatment, the curative effect of celiac effusion and TCM syndrome were observed, and the times of drainage of peritoneal effusion were recorded during the treatment. Results the effective rate of peritoneal effusion in the treatment group was 62.86, the stability rate was 85.71, in the control group it was 51.43% and 62.86, respectively. The stable rate in the treatment group was better than that in the control group (P 0.05). The number of drainage ascites in the treatment group was significantly less than that in the control group. Vomiting, diarrhea, neutropenia, The incidence of side effects of chemotherapy such as elevation of aminotransferase was significantly lower than that of control group P0.05.The curative effect of TCM syndrome in the treatment group was better than that in the control group. Conclusion the treatment of malignant peritoneal effusion caused by liver stagnation and spleen deficiency gastric cancer by the combination of Xiaotong Yi tumor recipe and intraperitoneal chemotherapy is better than that of the control group. Compared with chemotherapy alone, it can improve the stable rate of peritoneal effusion, reduce the times of drainage ascites, alleviate the side effects of chemotherapy, improve the syndrome of traditional Chinese medicine, and the clinical application is safe.
【作者单位】：福建省肿瘤医院;福建省中医药研究院;
【基金】：福建省自然科学基金(2015J01437) 福建省卫生计生委国家临床重点专科建设项目(2013年度)
【分类号】：R273

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