基于数据挖掘和网络药理学的儿童食积胃肠积热证组方用药规律及作用机制分析

发布时间：2018-03-18 04:33

  本文选题：食积　切入点：胃肠积热证　出处：《中华中医药杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的:挖掘儿童食积胃肠积热证的组方用药规律,分析处方可能存在的药物靶标及相互作用,探索核心药物的作用机制。方法:收集CNKI中关于儿童食积胃肠积热证的病例报道文献,采用TCMISS软件分析药物间的关联规则,挖掘核心药物及新处方;运用SPSS软件对药物的性味归经进行系统聚类分析;运用TCMSP、String及KEGG数据库分析新处方各药物靶标间相互作用关系及相关通路。结果:在筛选出的150首处方中,挖掘出6个核心药物组合和3首新处方,总结出性味归经相近的9个高频药群,得到新处方中相关药物靶标330个,这些靶标构成的网络中共存在相互作用2 961项、相关通路137条(FDR0.01),其中与消化系统关系最密切的7条。结论:治疗儿童食积胃肠积热证以消积导滞、理气健脾、清热除湿为主,其机制可能通过调控消化液的分泌,调控肠道消化及免疫、机体对微生物的免疫功能等多靶标复杂通路的共同干预实现。
[Abstract]:Objective: to explore the prescriptions of children with gastroenteric heat accumulation syndrome and analyze the possible drug targets and their interactions in the prescriptions. Methods: to investigate the mechanism of action of core drugs. Methods: collecting the case reports of children's gastroenteric heat syndrome in CNKI, using TCMISS software to analyze the association rules between drugs, excavating the core drugs and new prescriptions; SPSS software was used for systematic cluster analysis of drug quality and flavor, and TCMSPN String and KEGG database were used to analyze the interaction between drug targets and related pathways. Results: among the 150 selected prescriptions, Six core drug combinations and three new prescriptions were excavated, 9 high frequency drug groups with similar properties were summarized, 330 drug targets were obtained, and 2,961 interactions were found in the network composed of these targets. There are 137 related pathways of FDR 0.01, of which 7 are most closely related to digestive system. Conclusion: the treatment of children's syndrome of stomach and intestines accumulation and heat accumulation is mainly composed of eliminating accumulation and stagnation, regulating qi and invigorating spleen, clearing heat and dehumidification, and its mechanism may be through regulating the secretion of digestive fluid. Regulation of intestinal digestion and immunity, immune function of microorganism and other multi-target complex pathways to achieve joint intervention.
【作者单位】： 北京中医药大学中医学院;
【基金】：国家自然科学基金项目(No.81403328)~~
【分类号】：R272

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