中医药治疗Ⅳ期结直肠癌中医证候及用药规律文献研究

发布时间：2018-03-21 01:26

本文选题：结直肠癌　切入点：中医证型　出处：《中医杂志》2017年11期 　论文类型：期刊论文

【摘要】：目的通过文献统计分析,总结中医药治疗Ⅳ期结直肠癌患者的中医证型、中药使用规律以及中医药干预的治疗结局。方法检索1996年1月至2016年12月期间中国生物医学文献数据库、相关期刊论文、中文科技期刊数据库、万方数据库收录的涉及结直肠癌中医证候临床研究文献,对纳入文献中的中医证型、中药使用、治疗结局(包括卡氏评分、中位生存期、客观缓解率、疾病控制率)进行频次统计。结果共纳入文献58篇,患者4291例,其中有中医治疗者2438例,有中医证型者1586例。最常见的5个中医证型为脾肾阳虚(33.5%)、气血亏虚(17.4%)、瘀毒内阻(17.3%)、脾虚湿盛(16.0%)、湿热内蕴(13.8%)。58篇文献共出现中药138味,频次前5位的依次为白术(50)、茯苓(46)、黄芪(38)、党参(35)、薏苡仁(32)。28篇文献报告了治疗结局的卡氏评分,25篇(89.3%)结果有统计学意义;9篇文献报告了中位生存期,5篇(55.6%)结果有统计学意义;22篇文献报告了客观缓解率,9篇(40.9%)结果有统计学意义;15篇文献报告了疾病控制率,8篇(53.3%)结果有统计学意义(P0.05)。结论Ⅳ期结直肠癌中医证型具有本虚标实、虚实夹杂、易出现多脏亏虚的证候特点,扶正祛邪中药治疗在延长中位生存期、提高客观缓解率和疾病控制率等方面可能存在一定优势。
[Abstract]:Objective through literature statistical analysis, summarize the treatment stage of TCM syndromes in patients with rectal cancer node, the use of traditional Chinese medicine of Chinese medicine intervention treatment outcomes. Methods from January 1996 to December 2016 during the retrieval Chinese biomedical literature database, Chinese Journal Full-text Database, Chinese journals database, Wanfang database included relates to colorectal cancer syndromes the use of traditional Chinese medicine clinical research literature, in TCM, in the literature, the treatment outcome (including Karnofsky score, median survival, objective response rate, disease control rate) into the frequency statistics. Results a total of 58 articles were included, 4291 patients with Chinese medicine treatment of 2438 cases, 1586 cases TCM syndrome type. The 5 most common TCM Syndromes of spleen and kidney yang deficiency (33.5%), deficiency of Qi and blood stasis resistance (17.4%), (17.3%), spleen dampness, damp heat (16%) (13.8%).58 articles were out The 138 flavors of Chinese medicine, the frequency of the top 5 were Baizhu, Fuling (50) (46), Huangqi (38), dangshen, coix seed (35) (32).28 reported the treatment outcome of the Karnofsky score, 25 (89.3%) the results were statistically significant; 9 papers report the median survival period of 5 (55.6%), the results were statistically significant; 22 reported the objective response rate, 9 (40.9%) the results were statistically significant; 15 reported the disease control rate of 8 (53.3%), the results were statistically significant (P0.05). Conclusion IV node TCM Syndromes of rectal cancer with the vacuity, asthenia and sthenia syndrome characteristics, prone to dirty deficiency, Fuzhengquxie in Chinese medicine treatment and prolong the median survival time, improve the response rate and disease control rate may have some advantages.

【作者单位】：中国中医科学院西苑医院;新疆维吾尔自治区中医医院;
【基金】：国家自然科学基金(81373824) 北京市科技计划项目(Z131107002213101) 中国中医科学院自主选题项目(ZZ070854)
【分类号】：R273

【相似文献】