基于数据挖掘的柴可群教授辨治胃癌用药分析及经验总结

发布时间：2018-03-21 18:39

本文选题：胃癌　切入点：数据挖掘　出处：《浙江中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的运用“中医传承辅助平台”系统挖掘柴可群教授治疗胃癌的用药数据,总结柴可群教授治疗胃癌的临床经验,使之能够进一步指导中医药在胃癌治疗中的运用。方法采用回顾性调查的方法,收集柴可群教授2014年01月至2017年01月诊治的胃癌病案,将所用病案资料依次录入“中医传承辅助平台”系统(V2.50),并运用其集成的规则分析、改进互信息法、复杂系统熵聚类及无监督的熵层次聚类等数据挖掘方法,分析柴可群教授治疗胃癌的用药及总结经验。结果对108例胃癌患者,480个处方进行分析,统计处方中药物的使用频次,药物之间的关联规则,演化得到核心组合23个、新处方13个。结论通过对柴可群教授治疗胃癌用药的分析总结,得出柴可群教授在治疗胃癌特点:基于频数分析可知以扶正药为主,祛邪药为辅,适时佐以理气药,其中扶正药以补气、补阴较多,祛邪药则以化痰散结、清热解毒、化瘀散毒多见;基于关联规则分析得出的核心处方是太子参,茯苓,白术,甘草,半夏,黄芩,薏米仁;基于熵聚类的组方规律分析得出13新处方可归类为以下几种:①顾护脾胃,②疏肝和胃,③通降胃腑,④化痰解毒,⑤温阳化瘀,⑥经方化裁。认为胃癌的基本病机是“正虚为本、癌毒为患、情志失畅”,辨治胃癌主要有以下几个特点:①病证结合,中西合参;②扶正培本、抗癌祛邪;③整体局部,三因制宜;④分期而治,贵在对症;⑤通降胃腑,疏理气机;⑥温阳通络,顾及气阴;⑦调畅情志,注意饮食;⑧处方执简,用药轻灵。
[Abstract]:Objective to excavate the data of professor Chai Kequn in the treatment of gastric cancer by using the system of "Chinese Medicine inheriting and assisting platform", and summarize the clinical experience of Professor Chai Kequn in the treatment of gastric cancer. Methods retrospective investigation was used to collect the medical records of gastric cancer diagnosed and treated by Professor Chai Kequn from January 2014 to January 2017. The data of medical records are input into the system of "Chinese Medicine inheritance and Assistance platform" in turn, and the data mining methods such as mutual information method, entropy clustering of complex systems and unsupervised entropy hierarchical clustering are improved by using the integrated rule analysis. Results 480 prescriptions of 108 patients with gastric cancer were analyzed, the frequency of drug use in prescriptions, association rules between drugs were counted, and 23 core combinations were obtained. Conclusion the characteristics of professor Chai Kequn in the treatment of gastric cancer are as follows: based on the analysis of frequency, we can know that the main medicine is to strengthen the qi, the other is to dispel evil, and to assist in the treatment of gastric cancer. Among them, tonifying qi, tonifying yin, expelling evil drugs are phlegm dispersing, clearing away heat and detoxification, removing blood stasis and dispersing poison, the core prescription based on association rule is Radix Pseudostellariae, Poria cocos, Atractylodes macrocephala, Glycyrrhiza uralensis, Pinellia ternata, Scutellaria baicalensis, and Yimiren; Based on the rule analysis of entropy clustering, the 13 new prescriptions can be classified as the following kinds: 1: 1, protecting the spleen and stomach, 2 soothing the liver, and 3 opening up the stomach to reduce phlegm and detoxify the stomach. Fang Hua considers that the basic pathogenesis of gastric cancer is "positive deficiency is the basis." Differentiation and treatment of gastric cancer are mainly characterized by the following characteristics: 1. Combination of disease and syndromes, combination of Chinese and Western medicine, combination of ginseng and 2 tonics, anti-cancer, anti-evil, anti-cancer, anti-evil and anti-cancer, three should be treated by stages, mainly in treating the stomach by five channels and lowering the stomach entrails, as a result of the treatment of the disease by stages. Soothing Qi-Qi-Qi-Qi-Qi-Qi-Qi-Qi-Qi-Qi-Qi-Qi-Qi-Qi-Qi-Qi-Qi-Qi-Qi-Qi-Qi-Qi-Qi-Qi-Qi-Qi-Qi-Qi-Qi-
【学位授予单位】：浙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R249;R273

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