加味麻杏石甘汤配合穴位贴敷治疗老年慢性阻塞性肺病急性加重期患者的效果及对肺功能和肿瘤坏死因子-α、白细胞介素-8表达的影

发布时间：2018-03-22 02:38

本文选题：慢性阻塞性肺疾病　切入点：急性加重期　出处：《中国老年学杂志》2017年01期 　论文类型：期刊论文

【摘要】：目的探讨加味麻杏石甘汤配合穴位贴敷治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效及其对肺功能和肿瘤坏死因子(TNF)-α、白细胞介素(IL)-8表达的影响。方法 130例老年AECOPD患者随机分为对照组和观察组,对照组采用穴位贴敷治疗,治疗组在对照组的基础上加用加味麻杏石甘汤,治疗2 w后,观察两组治疗效果,肺功能及血清IL-8和TNF-α表达水平。结果观察组总有效率(93.33%)显著高于对照组(77.78%)(χ~2=4.406,P=0.036)。两组肺功能均较治疗前改善,观察组好转幅度大于对照组(P0.01)。两组血清TNF-α、IL-8炎性因子水平表达均降低,且观察组低于对照组(P0.05)。结论加味麻杏石甘汤配合穴位贴敷治疗AECOPD的临床疗效确切,可有效改善肺功能,降低血清TNF-α、IL-8炎性因子表达。
[Abstract]:Objective to investigate the clinical effect of modified maxingshigan decoction combined with acupoint application on chronic obstructive pulmonary disease (COPD) in acute exacerbation of chronic obstructive pulmonary disease (COPD) and its effect on lung function and expression of TNF- 伪 and IL-8 in 130 elderly patients. Patients with AECOPD were randomly divided into two groups: control group and observation group. The control group was treated with acupoint application, and the treatment group was treated with modified maxing Shigan decoction on the basis of the control group. After 2 weeks of treatment, the therapeutic effects of the two groups were observed. Results the total effective rate of the observation group was significantly higher than that of the control group (77.78) (蠂 ~ (2 +) 4.406). The pulmonary function of the observation group was improved compared with that of the control group (P 0.01). The level of serum TNF- 伪 IL-8 inflammatory factor in the observation group was lower than that in the control group (P < 0.05), and the expression of TNF- 伪 IL-8 was significantly higher in the observation group than that in the control group (P < 0.05), and the expression of TNF- 伪 IL-8 was significantly higher in the observation group than that in the control group. Conclusion the modified maxing Shigan decoction combined with acupoint application is effective in the treatment of AECOPD, which can effectively improve pulmonary function and reduce the expression of serum TNF- 伪 IL-8 inflammatory factor.
【作者单位】：河北省中医院呼吸一科;河北省中医院呼吸二科;辛集市第一医院外一科;河北省中医院脾胃病一科;河北省中医院内科;
【基金】：河北省中医药管理局科研计划项目(No.2014032)
【分类号】：R246.1

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