中药周期疗法治疗月经过少的系统评价

发布时间：2018-03-22 07:33

本文选题：中药周期　切入点：月经过少　出处：《辽宁中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:评价中药周期疗法治疗月经过少的有效性及安全性,促进中药周期疗法治疗月经过少的推广及应用。材料与方法:采用循证医学方法,根据文献的纳入标准与排除标准制定检索策略,计算机检索重庆维普数据库(VIP),中国生物医学期刊文献数据库(CBM),相关期刊论文(CNKI),万方数据库,Pubmed文献电子数据库,搜索有关中药分期疗法治疗月经过少的随机或半随机临床研究,筛选检索的文献,对纳入的文献进行方法学质量评价及风险偏倚评价,采用Revman5.3(Cochrane协作网提供的软件),进行Meta-分析。结果:1.根据制定的纳入标准与排出标准,共纳入17篇随机对照试验,包含1246例月经过少患者。2.Meta分析结果:(1)总有效率:中药周期疗法和其他疗法治疗月经过少总有效率比较,合并后的OR值为4.03,95%置信区间为[2.96,5.47],菱形位于中线的右侧,经Z检验,z=8.90,P0.0001,表明中医周期疗法治疗月经过少在总有效率方面高于西药、中成药或单纯口服中药组,差异有统计学意义。(2)子宫内膜厚度改善:中药周期疗法治疗月经过少较对照组在子宫内膜改善方面具有显著优势。结论:中药周期疗法治疗月经过少在总有效率、子宫内膜厚度、月经量改善等方面均比单纯口服中药、中成药或西药有优势(p0.05),但由于所纳入的文献数量有限,文献疗效判定标准不统一,且本研究收集的文献方法学质量偏低,因此论证强度较弱,期待有高质量、大样本的临床随机对照试验,为中药周期疗法治疗月经过少提供国内外学者可信的临床依据。
[Abstract]:Objective: to evaluate the efficacy and safety of periodic therapy for menorrhagia, and to promote the popularization and application of periodic therapy of traditional Chinese medicine in the treatment of menorrhagia. Materials and methods: Evidence-Based Medicine (EBM) was used. According to the criteria of inclusion and exclusion of literature, the retrieval strategy was formulated. The database of Weipu in Chongqing was searched by computer, the database of Chinese biomedical journals was CBMN, the full text database of Chinese periodicals was CNKII, and the electronic database of pubmed documents was published in Wanfang database. To search for random or semi-random clinical studies on the treatment of menorrhagia by stages therapy of Chinese medicine, to screen the literature retrieved, to evaluate the methodological quality and risk bias of the included literature. Meta- analysis was carried out by using software provided by Revman5.3(Cochrane collaboration Network. Results: 1.According to the inclusion criteria and exclusion criteria, 17 randomized controlled trials were conducted. 2. Meta-analysis results of 1246 patients with hypomenorrhea. 2. The total effective rate: compared with the total effective rate of Chinese medicine cycle therapy and other treatments, the combined OR value was 4.03% 95% confidence interval [2.96 卤5.47], and the rhombus was located on the right side of the median line. The Z test showed that the total effective rate of cycle therapy in treating menstrual insufficiency was higher than that in western medicine, traditional Chinese medicine or oral Chinese medicine group. The difference is statistically significant. 2) the improvement of endometrial thickness: Chinese medicine cycle therapy has a significant advantage over the control group in the improvement of endometrium. Conclusion: the total effective rate of Chinese medicine cycle therapy for menorrhagia is higher than that of the control group. Endometrial thickness and menstrual volume improvement have advantages over traditional Chinese medicine alone, traditional Chinese medicine or western medicine. However, due to the limited number of literature included, the criteria for evaluating the efficacy of the literature are not uniform, and the quality of the literature collected in this study is on the low side. Therefore, the demonstration intensity is weak and the clinical controlled trials of high quality and large sample are expected to provide a reliable clinical basis for the treatment of menorrhagia by Chinese medicine cycle therapy at home and abroad.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R271.111

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