健脾益肾法治疗雷公藤多甙片所致慢性肾小球肾炎女性患者性腺损害的临床观察

发布时间：2018-03-22 10:05

本文选题：慢性肾炎　切入点：性腺损害　出处：《北方药学》2017年04期 　论文类型：期刊论文

【摘要】：目的:观察健脾益肾方治疗雷公藤多甙片所致慢性肾小球肾炎女性患者性腺损害的临床疗效。方法:服用足量雷公藤多甙片后继发的以月经紊乱为主要临床表现的女性慢性肾小球肾炎患者60例分为两组,均接受贝那普利基础治疗,对照组30例给予半量雷公藤多甙片治疗,治疗组30例给予健脾益肾方合半量雷公藤多甙片治疗。两组均在用药3个月后观察疗效。结果:治疗组治疗后中医临床症候积分、生化指标(24h尿蛋白定量、血清白蛋白)均较对照组明显改善,差异有统计学意义(P0.05)。两组不良反应发生率比较,差异无统计学意义(P0.05)。结论:健脾益肾方联合半量的雷公藤多甙片用于治疗女性慢性肾小球肾炎疗效确切,对性激素水平的影响较小,但与对照组比较,健脾益肾汤尚未能显著改善性激素。
[Abstract]:Objective: to observe the clinical effect of Jianpi Yishen recipe on gonadal damage in female patients with chronic glomerulonephritis induced by Tripterygium wilfordii polyglycoside tablets. Sixty female patients with chronic glomerulonephritis were divided into two groups. All patients were treated with benazepril and 30 patients in the control group were treated with tripterygium wilfordii polyglycosides. 30 cases in the treatment group were treated with Jianpi Yishen decoction and half dose Tripterygium wilfordii polyglycoside tablets. Serum albumin was significantly improved compared with the control group, and the difference was statistically significant (P 0.05). The incidence of adverse reactions in the two groups was higher than that in the control group. Conclusion: Jianpi Yishen decoction combined with half dose of Tripterygium wilfordii polyglycoside tablet is effective in the treatment of chronic glomerulonephritis in female, and has little effect on sex hormone level, but compared with the control group. Jianpi Yishen decoction has not been able to significantly improve sex hormones.
【作者单位】：广东省深圳市中医院肾病科;
【分类号】：R277.5

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