胃得安胶囊治疗胃溃疡的临床疗效及相关作用机制研究

发布时间：2018-03-22 21:28

本文选题：胃得安胶囊　切入点：胃溃疡　出处：《时珍国医国药》2017年06期 　论文类型：期刊论文

【摘要】：目的探索胃得安胶囊治疗胃溃疡愈合的临床疗效及相关作用机制。方法将64例胃溃疡患者随机分成对照组和观察组,每组32例,对照组采用常规的三联疗法,即口服奥美拉唑肠溶胶囊(20 mg/次,2次/d)+克拉霉素胶囊(0.25 g/次,2次/d)+阿莫西林胶囊(0.5 g/次,2次/d),观察组在此基础上加用胃得安胶囊。两组均以吃药4周为1个疗程,治疗前后均行胃镜检查,取溃疡黏膜组织进行COX-1、COX-2、PGE2免疫组织化学染色检测,检测血清TFF2及SOD水平,并比较两组临床疗效。结果与治疗前比较,两组治疗后溃疡黏膜组织中COX-1、COX-2、PGE2表达水平均明显升高(P0.05),且观察组COX-1、COX-2、PGE2表达水平显著高于对照组(P0.05);与治疗前比较,两组治疗后TFF2、EGF均明显上升,且观察组TFF2、EGF水平上升程度明显高于对照组(P0.05);治疗组有效率显著高于对照组(P0.05)。结论胃得安胶囊可显著提高三联疗法对胃溃疡的疗效,其作用机制可能是通过增加溃疡黏膜组织中COX-1、COX-2的表达和PGE2的分泌,提高TFF2及EGF水平,从而促进溃疡的愈合,提高溃疡愈合质量。
[Abstract]:Objective to explore the clinical effect and related mechanism of Weidian capsule in the treatment of gastric ulcer healing. Methods 64 patients with gastric ulcer were randomly divided into two groups: control group (n = 32) and observation group (n = 32). That is, oral omeprazole enteric-coated capsule (20 mg/ / twice / d) clarithromycin capsule 0.25g / twice / twice / d) amoxicillin capsule 0.5g / twice / twice / d, the observation group added Wedelan capsule on this basis. Both groups took medicine for 4 weeks as a course of treatment. Gastric endoscopy was performed before and after treatment, and the mucosal tissue of ulcer was detected by immunohistochemical staining for COX-1 and COX-2 PGE2. The serum levels of TFF2 and SOD were detected, and the clinical efficacy of the two groups was compared. After treatment, the expression of COX-1, COX-2 and PGE2 in ulcerative mucosa was significantly increased in both groups, and the expression level of COX-1, COX-2 and PGE2 in the observation group was significantly higher than that in the control group (P 0.05), and the expression of TFF2EGF in both groups was significantly higher than that in the control group before and after treatment. The level of TFF2 + EGF in the observation group was significantly higher than that in the control group (P 0.05), and the effective rate in the treatment group was significantly higher than that in the control group (P 0.05). Conclusion Weidian capsule can significantly improve the efficacy of triple therapy in the treatment of gastric ulcer. The mechanism may be to increase the expression of COX-2 and the secretion of PGE2 in the mucous membrane of ulcers, and to increase the levels of TFF2 and EGF, so as to promote the healing of ulcers and improve the quality of ulcer healing.
【作者单位】：南华大学附属第二医院;湖南中医药大学药学院;
【分类号】：R259

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