自拟抑疡颗粒治疗消化性溃疡（肝胃郁热型）的临床研究

发布时间：2018-03-22 22:06

本文选题：消化性溃疡　切入点：肝胃郁热　出处：《长春中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:通过观察抑疡颗粒治疗消化性溃疡(肝胃郁热型)的临床疗效,以证明本方能明显改善患者的临床症状,对提高消化性溃疡(肝胃郁热型)的治疗水平具有积极意义。方法:本研究取符合消化性溃疡(肝胃郁热型)诊断标准的患者72例,随机分为治疗组和对照组各36例。其中治疗组:给予由长春中医药大学附属医院免煎药房提供的抑疡颗粒,1付温水冲服300ml,150ml日2次早晚口服;对照组:给予由大连泛美药业有限公司(批准文号:国药准字Z10970079)生产的溃得康颗粒,10g/次,2次/日口服。两组疗程均为28天。经统计学分析,以中医症候评定标准和胃镜作为评价指标进行评定。结果:1、本研究实际入组72例,脱落及剔除病例均为0例,两组患者依从性良好。2、疗效分析治疗28天后,两组治疗后症状总积分比较,经统计学处理,P0.01,有统计学意义。治疗后次要症状比较,在改善喜冷饮、嘈杂、便秘等症状方面,经统计学处理,P0.05,无统计学意义。在改善吞酸、情绪抑郁或烦躁易怒症状方面,治疗组优于对照组,经统计学处理,P0.05,有统计学意义。治疗后两组中医证候疗效比较,治疗组的中医证候疗效优于对照组,经统计学处理,P0.05,有统计学意义。治疗后两组胃镜疗效比较,经统计学处理,P0.05,无统计学意义。3、两组患者在服药期间均未发生不良反应事件。结论:抑疡颗粒治疗组可以有效地治疗消化性溃疡(肝胃郁热型),临床疗效优于溃得康颗粒,两组药物均能有效地改善中医证候。但抑疡颗粒可以改善胃脘疼痛、口干口苦、胃脘部灼热、吞酸、情绪抑郁或烦躁易怒等症状,值得临床进一步研究。
[Abstract]:Objective: to observe the clinical effect of Yaoyang granule in the treatment of peptic ulcer (liver-stomach stagnation and heat type), so as to prove that the prescription can obviously improve the clinical symptoms of the patients. Methods: 72 cases of peptic ulcer (hepatogastric stagnation and heat type) who met the diagnostic criteria of peptic ulcer (liver-stomach stagnation) were studied. The patients in the treatment group were randomly divided into treatment group (n = 36) and control group (n = 36). The control group was given 10g of Kuidekang granules produced by Dalian Pan am Pharmaceutical Co., Ltd (approval symbol: Z10970079) twice a day. The course of treatment in both groups was 28 days. The evaluation criteria of TCM symptoms and gastroscopy were used as the evaluation criteria. Results: one, 72 cases were actually included in this study, and 0 cases were dropped off and eliminated. The compliance of the two groups was good. The therapeutic effect was analyzed 28 days after treatment. The total score of symptoms after treatment in the two groups was statistically analyzed (P 0.01), which was statistically significant. After treatment, there was no statistical significance in the improvement of symptoms such as cold drinks, noise, constipation and other symptoms, such as cold drinks, noise, constipation, etc. In terms of emotional depression or irritability and irritability, the treatment group was better than the control group, and the treatment group was better than the control group. After statistical treatment, P 0.05, there was statistical significance. After treatment, the curative effect of gastroscope was compared between the two groups. There were no adverse events in both groups. Conclusion: YYYG treatment group can effectively treat peptic ulcer (liver and stomach stagnation and heat type), and the clinical effect is better than Kuidekang granule. Both drugs can effectively improve TCM syndromes, but Yiyang granule can improve the symptoms of epigastric pain, dry mouth, burning heat, acid swallow, emotional depression or irritability and irritability, and so on, which is worthy of further clinical study.
【学位授予单位】：长春中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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