补肾调周法治疗封闭抗体不足性复发性流产的临床研究

发布时间：2018-03-23 01:34

本文选题：补肾调周法　切入点：复发性流产　出处：《南京中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：观察中医补肾调周法治疗封闭抗体不足性复发性流产的临床疗效,并探讨其作用机理,为日后临床推广以及应用提供依据。方法：收集符合纳入标准的封闭抗体不足性复发性流产非妊娠期患者30例(证属脾肾两虚),予补肾调周中药序贯口服,3个月1个疗程,共两个疗程。观察：1.治疗后临床症状、体征改善情况；2.治疗后血封闭抗体变化情况;3.治疗后血Th1 (IL-8)、Th2 (IL-6)细胞因子及Th1(IL-8)/Th2 (IL-6)水平的变化；4.治疗后患者的妊娠情况。结果：1、补肾调周法不仅能显著改善患者的临床证候,还可有效提高患者外周血抗CD3-BE、抗CD8-BE的阳性率,降低IL-8水平和IL-8/IL-6比值,升高外周血IL-6水平,但对抗CD4-BE无明显影响。以上免疫指标于治疗前后相比较,P均0.05,有统计学意义。2、两个疗程后,30例患者中有7例再次妊娠,其中,6例获得成功,1例再次流产,妊娠成功率为20%。3、本课题30例患者经治疗,6例痊愈,占20%；18例显效,占60%；5例有效,占16.7%；总有效率96.7%。结论：补肾调周法治疗封闭抗体不足性复发性流产疗效确切,既可双向调节人的免疫功能,促进外周血抗CD3-BE和抗CD8-BE转阳,减少Thl细胞因子的分泌,促进Th2细胞因子的释放,调节Th1/Th2,促进同种免疫耐受的建立,又能显著减轻患者脾肾两虚的病候,改善妊娠结局,而且用药相对安全,易于患者接受,在同种免疫型复发性流产的防治中具有广阔的应用前景。
[Abstract]:Objective: To observe the clinical curative effect of traditional Chinese medicine Bushen Tiaozhou therapy blocking antibody deficiency of recurrent spontaneous abortion, and to explore its mechanism, provide the basis for clinical promotion and application after. Methods: We collected in accordance with the inclusion criteria of blocking antibody deficiency of recurrent spontaneous abortion (30 cases of patients with non pregnancy syndrome is the spleen kidney two falsely) for traditional Chinese medicine Bushen Tiaozhou, sequential oral, 3 months of 1 courses, a total of two courses: 1.. Observation after treatment, clinical symptoms, signs of improvement after treatment; 2. blood blocking antibody changes; 3. after treatment, blood Th1 (IL-8), Th2 (IL-6) cytokines and Th1 (IL-8) /Th2 (IL-6) level changes; pregnancy in 4. after treatment. Results: 1, the clinical syndrome of tkrpm can significantly improve the patients, but also can effectively improve the blood anti CD3-BE patients, the positive rate of CD8-BE, decrease the level of IL-8/IL-6 and the ratio of IL-8, the increase of IL in peripheral blood The level of -6, but no significant effect against CD4-BE. The above immune indexes before and after treatment comparison, P was 0.05,.2 was statistically significant, after two month treatment, 30 cases in 7 cases of pregnancy, among them, 6 were successful, 1 cases of abortion, pregnancy success rate is 20%.3, this topic 30 cases were cured, 6 cases were cured, accounting for 20%; 18 cases were cured, accounting for 60%; 5 cases were effective, accounting for 16.7%; the total efficiency was 96.7%. conclusion: the curative effect in the treatment of recurrent spontaneous abortion by blocking antibody deficiency the exact method of invigorating kidney and regulating menstruation, immune function can promote the two-way regulation of the peripheral blood and anti CD3-BE anti CD8-BE seroconversion, reduce the secretion of Thl cytokines, Th2 promotes the release of cytokines, regulate Th1/Th2, promote the establishment of immune tolerance, and can significantly reduce the symptoms of patients with spleen and kidney two empty, improve the outcome of pregnancy, and the medication is relatively safe and is easily accepted by patients, in alloimmune recurrent flow The prevention and control of production has a broad application prospect.

【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R271.9

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