温解汤对复发性口腔溃疡（寒热错杂型）患者CD4、CD8及补体C3、C4的影响

发布时间：2018-03-23 15:36

本文选题：复发性口腔溃疡　切入点：温解汤　出处：《河南中医药大学》2016年硕士论文

【摘要】：目的:本实验拟通过观察温解汤对复发性口腔溃疡(RAU)患者症状、体征及T淋巴细胞亚群CD4、CD8及补体C3、C4的影响,并与临床常用药物罗红霉素胶囊联合维生素B2效果进行比较,综合评价温解汤,并进而探究其可能的作用机理,为临床防治和新药研发提供充分的理论支撑。方法:将2014年6月-2015年12月在河南中医药大学第三附属医院消化科、口腔科门诊确诊为RAU(寒热错杂型)的患者,共60例,按就诊顺序编为1-60号,随机分为两组,即温解汤治疗组、西药对照组,各30例。治疗组给予温解汤,西药对照组:罗红霉素胶囊,维生素B2。治疗10天后,评价其临床症状、体征及安全性指标,并用实验方法测量患者CD4、CD8及补体C3、C4的含量变化,继续给药5天巩固治疗,随访3个月。结果:1安全性:两组患者心电图及常规生化检查无异常,未出现不良反应;2临床证候:两组患者口腔溃疡面积、数目、疼痛程度、创面愈合情况等各项证候、体征较治疗前均有改善P)05.0(,温解汤治疗组、西药对照组总有效率分别为93%、86%,无显著差异P)05.0(。3检测指标:两组患者在规范服药一疗程后,CD4及补体C3、C4水平均增高P)05.0(,CD8水平下降P)05.0(,且治疗后温解汤治疗组与西药对照组差异不明显P)05.0(。4远期疗效:温解汤治疗组三月内复发率%19,西药对照组三月内复发率高达%84,其差异有显著统计学意义P)01.0(。结论:温解汤治疗RAU寒热错杂型,能大大缩短患者病程,缓解痛苦,降低复发率,在症状改善方面成果显著。在规范治疗一个疗程后对CD4及血清补体C3、C4水平有上调作用,同时降低CD8水平,验证了该指标与RAU的密切关系。与西药对照组相比,局部病损恢复及证候疗效相当,但在长期疗效方面有显著优势,且实验中无明显不良事件发生,效佳,安全无副作用。
[Abstract]:Objective: to observe the effects of Wenjie decoction on symptoms, signs, T lymphocyte subsets CD4C 8 and complement C 3 C 4 in patients with recurrent oral ulcer (Rau), and to compare the effects with roxithromycin capsule combined with vitamin B2. In order to provide sufficient theoretical support for clinical prevention and treatment and new drug research and development, Wenjie decoction was comprehensively evaluated and its possible mechanism was explored. Methods: from June 2014 to December 2015, Department of Digestive Sciences, third affiliated Hospital of Henan University of traditional Chinese Medicine, was selected. A total of 60 patients diagnosed as Rau (cold and heat disorder type) in outpatient department of stomatology were randomly divided into two groups: Wenjie decoction treatment group, western medicine control group, 30 cases each. The treatment group was given Wenjie decoction, and the western medicine control group was treated with Wenjie decoction. The western medicine control group: roxithromycin capsule, vitamin B2. After 10 days of treatment, the clinical symptoms, signs and safety indexes were evaluated, and the changes of CD _ 4, CD _ 8 and complement C _ 3N _ 4 were measured by the experimental method. Results: there was no abnormal electrocardiogram and routine biochemical examination, and no adverse reactions were found in the two groups: the area of oral ulcer, the number of patients, the degree of pain, wound healing and other syndromes in the two groups. The physical signs were improved before treatment, and the treatment group was treated with Wenjie decoction. The total effective rate of the western medicine control group was 935.86 and there was no significant difference between the two groups: after a course of standardized treatment, the levels of CD _ 4 and C _ 3N _ 4 in the two groups were increased, the levels of P _ (05.0) and CD _ 8 were decreased, and the difference between the treatment group and the western medicine control group was also found after the treatment. The long term curative effect of PX05.04.The relapse rate in the treatment group was higher than that in the western medicine control group, and the recurrence rate in the treatment group was as high as that in the western medicine control group. Conclusion: Wenjie decoction can shorten the course of disease, ease the pain and reduce the recurrence rate of RAU, which can greatly shorten the course of disease, alleviate the pain and reduce the recurrence rate. After a course of standardized treatment, the levels of CD4 and serum complement C _ 3N _ 4 were upregulated, and the level of CD8 was decreased, which verified the close relationship between the index and RAU. The recovery of local lesions and syndromes were similar, but there were significant advantages in long-term efficacy, and there were no obvious adverse events in the experiment, good effect, safety and no side effects.
【学位授予单位】：河南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R276.8

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