枇杷清肺饮加减联合靓芙康复贴敷料治疗轻中度寻常痤疮的临床疗效观察

发布时间：2018-03-24 19:16

本文选题：枇杷清肺饮加减　切入点：生物敷料　出处：《南京中医药大学》2016年硕士论文

【摘要】：目的：观察枇杷清肺饮加减方联合靓芙康复贴敷料治疗轻中度寻常痤疮的临床疗效和安全性。方法：将90例中医辨证为肺经风热证的寻常痤疮患者,随机分三组：A组、B组及C组各30例,其中C组1例失访,最后89例患者进入统计分析。A组采用枇杷清肺饮加减联合靓芙康复贴敷料进行治疗；B组,单用枇杷清肺饮加减进行治疗；C组单用靓芙康复贴敷料进行治疗；治疗4周后进行疗效判定。治疗前后根据总皮损数目的变化作临床疗效评价；根据中医证候积分变化情况进行中医证候的疗效评价；根据皮肤临床状况总积分变化情况作皮肤临床改善情况的评价。根据安全性指标变化情况做安全性评价。结果：经4周治疗后,三组患者总皮损数均较治疗前下降,治疗前后差异均有统计学意义(P0.05),相较于C组, A、B两组的下降幅度更大。治疗结束后A组的总有效率为80.00%,B组总有效率为50.00%,C组总有效率为20.69%,三组临床疗效比较差异有统计学意义(P0.05)。三组治疗后肺经风热证的症状及体征均较治疗前改善,与之相应的中医证候总积分与治疗前相比也均有显著性差异(P0.05),治疗结束后A组、B组及C组中医证候疗效的总有效率分别为76.67%、70%和17.24%,A、B两组比较中医证候疗效无显著性差异(P0.05),且均显著优于C组(P0.05)。在改善皮肤临床情况方面,治疗中采用靓芙康复贴敷料的A组与C组,治疗后两组患者皮肤临床情况总积分均较治疗前显著下降(P0.05),而B组患者治疗前后无显著性差异(P0.05)。治疗结束后三组患者均未出现严重不良反应,A组3例与B组2例,服中药后出现轻度胃部不适,调整服药时间及服药方法后,不适症状消失。治疗前后各项指标均在正常参考值范围之内。结论：枇杷清肺饮加减联合靓芙康复贴敷料治疗轻中度寻常痤疮,安全有效,可以作为治疗轻中度寻常痤疮临床选择,为其治疗提供了新思路；联合治疗组在治疗的同时,对患者的皮肤情况起到改善作用,可以增加患者的舒适度及满意度,提高患者的依从性。
[Abstract]:Objective: to observe the clinical efficacy and safety of loquat Qingfei decoction combined with Liangfukangtan dressing in the treatment of mild to moderate acne vulgaris. Methods: 90 cases of acne vulgaris with syndrome differentiation of lung meridian and wind heat were treated with traditional Chinese medicine. They were randomly divided into three groups: 30 cases in group A, 30 cases in group B and 30 cases in group C. among them, one case in group C was lost, and 89 cases in group A were treated with loquat Qingfei Yin plus subtraction plus Fuliangfu plaster dressing, and group B was treated by adding and subtracting loquat Qingfei Yin with Fuliangfu plaster. The treatment group C was treated with Liangfu rehabilitation plaster alone, the curative effect was judged after 4 weeks of treatment, and the clinical curative effect was evaluated according to the changes of the total number of skin lesions before and after treatment. To evaluate the curative effect of TCM syndrome according to the change of TCM syndromes integral; The clinical improvement of skin was evaluated according to the total integral change of skin clinical condition and the safety evaluation was made according to the change of safety index. Results: after 4 weeks of treatment, the total number of skin lesions in the three groups was lower than that before treatment. The difference before and after treatment was statistically significant (P 0.05). Compared with group C, the decrease of Agna B group was greater. After the treatment, the total effective rate of group A was 80.00cm. The total effective rate of group B was 50.00cm. The total effective rate of group C was 20.69. There was a difference among the three groups in clinical efficacy. After treatment, the symptoms and signs of lung meridian heat syndrome in the three groups were improved compared with those before treatment. There were significant differences in the total integral of TCM syndromes compared with those before treatment. After the treatment, the total effective rates of TCM syndromes in group A and group C were 76.67% and 17.24% respectively. There was no significant difference between group A and group C in TCM syndromes. The difference of P0.05 was significantly better than that of group C in improving the clinical condition of skin. Group A and group C were treated with Liangfu rehabilitation dressing. After treatment, the total clinical score of skin in both groups was significantly lower than that before and after treatment, but there was no significant difference between group B and group B. after the treatment, there were no serious adverse reactions in group A (3 cases) and group B (2 cases). After taking traditional Chinese medicine, there is mild stomach discomfort, after adjusting the time and method of taking medicine, All indexes were within the normal reference value before and after treatment. Conclusion: it is safe and effective to treat mild to moderate acne vulgaris by adding and subtracting loquat Qingfei Yin and Liangfu Kangfeng paste dressing. It can be used as a clinical choice for the treatment of mild to moderate acne vulgaris, and provides a new idea for the treatment of acne vulgaris. The combined treatment group can improve the skin condition of the patients and increase the comfort and satisfaction of the patients. Improve compliance of patients.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R275.9

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