基于fMRI技术针刺足太阳膀胱经飞扬穴脑激活区特异性研究

发布时间：2018-03-25 20:15

本文选题：功能磁共振成像　切入点：飞扬穴　出处：《黑龙江中医药大学》2017年硕士论文

【摘要】：目的:应用血氧水平依赖功能磁共振成像技术(Bold-fMRI)获得健康被试者针刺右侧足太阳膀胱经飞扬穴及其对应非穴引起脑激活区数据,结合中医经络及脑神经学知识试探寻针刺飞扬穴产生疗效的机制,通过对针刺飞扬穴与对应非穴引起脑激活区进行比较,证明针刺飞扬穴可引起相关脑区特异性激活,为腧穴特异性研究提供更直观可视化影像学依据。方法:选取20名黑龙江中医药大学在读健康男性右利手研究生作为本次实验被试者,使用飞利浦3.0T双源双梯度磁共振扫描仪收集被试者针刺右侧足太阳膀胱经飞扬穴及其非穴的脑Bold信号图像数据,通过SPM12软件对图像数据进行后处理及统计学分析后,最终获得针刺飞扬穴及对应非穴引起的脑激活区位置、体素值、激活程度等信息。结果:1.针刺健康被试者右侧飞扬穴引起正激活脑区主要包括:左侧中央后回、小脑、颞上回、顶叶,右侧小脑、岛叶、中脑、丘脑、颞上回、额中回。2.针刺健康被试者右侧飞扬穴引起负激活脑区主要包括:左侧边缘叶、梭状回、前扣带回、中央后回、中脑,右侧海马回、杏仁核、额叶、小脑后叶、枕叶。3.针刺健康被试者右侧飞扬穴非穴引起的激活脑区主要包括:左侧小脑前叶、岛叶、顶下小叶、边缘叶、额上回,右侧额中回、岛叶。4.针刺健康被试者右侧飞扬穴非穴无负激活脑区。结论:1.针刺健康被试者右侧飞扬穴可引起脑激活区呈现特异性反应。2.针刺同一经络上不同腧穴可引起相似的大脑反应。3.针刺飞扬穴治疗腰椎间盘突出症引起疼痛的机制可能与其调节下丘脑、中脑、海马回、杏仁核及扣带回等多个脑区神经元活动有关。4.针刺飞扬穴非穴引起的激活脑区可能与被试者"应激状态"有关。
[Abstract]:Objective: to obtain the data of brain activation region caused by acupuncture of the right foot and bladder through Feiyang point and its corresponding non-point by using blood oxygen level dependent functional magnetic resonance imaging technique (Bold-f MRI) in healthy subjects. Combined with the knowledge of meridian and neurology of traditional Chinese medicine, this paper tries to explore the mechanism of finding acupuncture at Feiyang point to produce curative effect. By comparing the brain activation area caused by acupuncture at Feiyang point and corresponding non-point, it is proved that acupuncture at Feiyang point can cause specific activation of relevant brain region. Methods: twenty healthy male right-handed graduate students in Heilongjiang University of traditional Chinese Medicine were selected as subjects. Philips 3.0T dual-source double-gradient magnetic resonance scanner was used to collect the brain Bold signal data of the right foot, which were punctured by the right foot, the bladder meridian point and its non-point. The image data were processed and statistically analyzed by SPM12 software. Finally, the information of the position, voxel value and activation degree of brain activation area caused by acupuncture at Feiyang point and its corresponding non-acupoints were obtained. Results 1. The positive activation area caused by acupuncture at the right Feiyang point of healthy subjects mainly includes: left posterior central gyrus, cerebellum, superior temporal gyrus, etc. Parietal lobe, right cerebellum, island lobe, midbrain, thalamus, superior temporal gyrus, middle frontal gyrus. 2. Acupuncture of right Feiyang point in healthy subjects mainly includes: left marginal lobe, fusiform gyrus, anterior cingulate gyrus, central and posterior gyrus, midbrain. Right hippocampus, amygdaloid nucleus, frontal lobe, posterior cerebellar lobe, occipital lobe, and occipital lobe. The active brain areas caused by acupuncture at right Feiyang point mainly include: left cerebellum anterior lobe, island lobe, inferior parietal lobule, marginal lobe, superior frontal gyrus, right middle frontal gyrus, right middle frontal gyrus. (4) Acupuncture of the right Feiyang point of the healthy subjects has no negative activation of brain area. Conclusion: 1. Acupuncture on the right side of the Feiyang point of the healthy subjects can cause a specific response of the brain activation region. 2. Acupuncture at different acupoints on the same meridian may cause the similarity. The mechanism of acupuncture at Feiyang point in the treatment of pain caused by lumbar disc herniation may be similar to its regulation of hypothalamus. The activity of neurons in the mesencephalon, hippocampal gyrus, amygdala and cingulate gyrus is related to .4.Activating brain area caused by acupuncture at Feiyang point may be related to the "stress state" of the subjects.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R445.2;R246

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